李世元

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李世元（Adam Shih-Yuan Lee）

有機化學、藥物合成、材料合成

淡江大學化學系教授(1998.5-迄今)
淡江大學生命科學研究所合聘教授(2003.8-迄今)
淡江大學化學系系主任(2001.8-2005.7)
淡江大學化學系副教授(1993.8-1998.4)
美國愛莫利大學博士後研究(1992-1993)
美國加州大學河濱分校博士(1988-1991)
美國加州大學河濱分校碩士（1986-1988）
淡江大學化學系儀器分析助教（1985-1986）
淡江大學化學系化學系學士（1985）

Tamkang University, Professor
Graduate Institute of Life Sciences, Joint Professor
Department of Chemistry, Chairman
Tamkang University, Associate Professor
Emory University, Postdoctorate
University of California, Riverside, Ph. D.
University of California, Riverside, M. S.
Tamkang University, Teaching Assistant
Tamkang University, B. S.

教師歷程系統

辦公室：C601
實驗室：C602~C606
TEL : (02) 2621-5656 轉 2543
Email address: adamlee@mail.tku.edu.tw

研究專長及興趣

有機化學藥物合成材料合成超音波化學

本實驗室長期持續的研究發展方向為

(A)新的位相選擇性和立體選擇性有機反應和方法合成生物活性分子

(a)b-取代羰化合物，如b-胺基、b-氫氧基、b -醯胺基、b-烷氧基酮/酯、b-胺基酸、b-胜肽、a-氫氧基-b-胺基酸。

(b)4至7環的雜環化合物，如b-環內醯胺、b-環內酯、a-亞甲基-γ-環內醯胺/γ-環內酯、吡咯、吡咯啶、哌喃酮及哌吡啶、、等。

(B)有機光電材料合成及其應用研究，如有機電激光、有機場效應電晶體和有機螢光材料。

(C)合成蛋白質生物晶片之新的生物連結分子並研究其在各種金屬表面的分子自我組裝(SAM)性質，亦研發合成有機感測分子(抗原-抗體，重金屬)在生物晶片檢測之應用。

近期代表性研究成果為研發可同時抗病毒、抗細菌和抗黴菌的有機化合物，Anti-VBF，SGS檢測報告顯示Anti-VBF可於五秒內即抑制（＞99.9 ％）抗藥性金黃色葡萄球菌、肺炎克雷白桿菌、緑膿桿菌、沙門氏菌、大腸桿菌。這極佳的成果是延續2009年時研發VirusBom(或稱病毒崩,商業週刊,2009,1133期, Aug.10, P.46;可抗新流感病毒(H1N1)，禽流感病毒(H5N1，H5N2)，腸病毒，金黃色葡萄球菌)的研發成果再突破而獲得的。數年前研發的台大奈米生醫一號(8-氫氧基辛烷酸，或稱台大抗煞一號)衍生的有機化合物也被研發証實為新的不含氟有機駐極体(Eletret)，可應用於駐極體揚聲器或靜電吸附濾清材質(Shih-Yuan Lee; Chih-Kung Lee; Wen-Ching Ko; Jia-Lun Chen; Ing Yih Leu; Wen-Hsin Hsiao; Wen-Jong Wu "ELECTRET MATERIALS, E LECTRET SPEAKERS, AND METHODS OF MANUFACTURING THE SAME", US Patent US 2009/0245547 A1 (Oct. 1, 2009)。

另一代表性研究成果為研發以電性感測之抗體探針偵檢及量測感測方法，突破以電化學、力學或光學感測模式，可應用於即時監測檢測系統儀器開發和製造。已獲得多項美國專利。

The long-standing goals of this laboratory are to develop the following:

(A) Novel regioselective and stereoselective organic reactions including methods for synthesis of potential biological active molecules such as

(a) b-Substituted carbonyl compounds and their derivatives such as b-amino, b-hydroxy, b-amido, b-alkoxy, b-halo ketone/ester, b-amino acid, b-peptide, and a-hydroxy-b-amino acid.

(b) 4- to 7-Member ring heterocyclic compounds such as b-lactam, b-lactone, a-methylene-g-lactone/ g-lactam, pyrrole, pyrrolidine, pyrazole, isoxazole, tetrahydrofuran, pyranone, piperidine, piperazine and diazepine.

(B) Synthesis of new organic electroptical materials such as electroluminesencent, organic field effect transistors (OFET) and fluororescent organic compounds.

(C) Synthesis of new bio-linkers for protein biochips in addition to studying their self assembled monolayer (SAM) properties on various surfaces, especially aim to the conductiing and electroluminesencent properties.

(D) Recent important results include the discovery of some new antivirus (avian influenza) and antibacterial (Staphylococcus aureus) agents as well as the creation of a new organic compound, otherwise known as VirusBom, which has been successfully transferred to industry for commercial mass production.

榮譽與獎勵

國科會傑出技術移轉貢獻獎 2005

國科會補助大專院校獎助特殊優秀人才獎勵 2010, 2011, 2012, 2013, 2014, 2015

國科會研究獎勵 2002,2003,2004,2005,2006,2007,2008,2009,2010,2011,2012, 2013,2014

淡江大學教學特優教師獎 1999

淡江大學專題研究成效卓著獎 1996,1997,1998,1999,2000,2001,2002,2003,2004,2005,2006, 2007,2008,2009,2010,2011,2012,2013,2014,2015

淡江大學研究獎勵 1995,1996,1997,1998,1999,2000,2001,2002,2003,2004,2005, 2006,2007,2008,2009,2010,2011,2012,2013,2104,2015

國科會甲種研究獎 1994,1997,1998,1999

Journal of Applied Science and Engineering (EI) Associate Editor 2011起-

The ScientificWorld JOURNAL (SCI,IF=1.52) Editor-Organic Chemistry 2011起-

97年考試院考選部-特種考試地方政府公務人員考試閱卷委員 2008

101年考試院考選部-特種考試地方政府公務人員考試典試委員 2012

考試院考選部-有機化學題庫小組命題暨審查委員 2011-2012

104年公務人員高等考試三級考試暨普通考試命題兼閱卷委員 2015

中華臨床醫葯雜誌 (Chinese Journal of Medicine) 2007起- Executive Chief Editor

台北市中小學科學展覽會-台北市教育局作品說明書暨作品板審查委員第39屆-第48屆(2015)

期刊論文

1. Adam Shih-Yuan Lee*, Hsiu-Chih Yeh and Ming-Hung Tsai "A Simple and Highly Chemoselective Desilylation of tert-Butyldimethylsilyl Ethers", Tetrahedron Letters, 1995, 36, 6891-6894. (SCI, Citation Number = 44; This paper was selected and presented as a model reaction in "Synthetic Organic Sonochemistry" Luche, J.-L., ed.,Plenum Press: New York, 1998, p.69)

2. Adam Shih-Yuan Lee*, Hsiu-Chih Yeh and Ming-Hung Tsai " An Efficient and Highly Chemoselective Method to Desilylate Silyl Ethers", Journal of Chinese Chemical Society, 1995, 42, 919-922. (SCI Citation Number = 4; This paper was selected and presented as a model reaction in "Synthetic Organic Sonochemistry" Luche, J.-L., ed.,Plenum Press: New York, 1998, p.69)

3. Adam Shih-Yuan Lee* and Wen-Chin Dai "A Simple and Highly Efficient Preparation of Arylstannane via Sonochemical Barbier Reaction", Tetrahedron Letters, 1996, 37, 495-498. (SCI, Citation Number = 9)

4. Adam Shih-Yuan Lee* and Chin-Chun Kung "A Facile Synthesis of Aldehyde and Ketone via Sonochemical Barbier Reaction and Oxidation", Journal of Chinese Chemical Society, 1997, 44, 65-69. (SCI, Citation Number = 5)

5. Adam Shih-Yuan Lee* and Wen-Chin Dai "A Facile and Highly Efficient Sonochemical Synthesis of Organostannane via Barbier Reaction", Tetrahedron, 1997, 53, 859-868. (SCI, Citation Number = 30; This paper was selected and presented as a model reaction in "Synthetic Organic Sonochemistry" Luche, J.-L., ed.,Plenum Press: New York, 1998, p.212)

6. Adam Shih-Yuan Lee*,Shi-Lien Zhang and Ohm-Guo Pan "Lewis Acid-Promoted Reduction of Bis(Triorganotin) Oxides to Hexaorganoditins", Journal of Chinese Chemical Society, 1997, 44, 625-628. (SCI, Citation Number = 5)

7. Adam Shih-Yuan Lee* and C.-L. Cheng, "A novel and Selective Method for Hydrolysis of Acetals and Ketals", Tetrahedron, 1997, 53, 14255-14262. (SCI, Citation Number = 26)

8. Adam Shih-Yuan Lee*, Rae-Yi Cheng and Ohm-Guo Pan " A Simple and Highly Efficient Synthesis of ß-Amino-α,ß-unsaturated Ester via Sonochemical Blaise Reaction", Tetrahedron Letters, 1997, 38, 443-446. (SCI, Citation Number = 47; This paper was selected and presented as amodel reaction in "Synthetic Organic Sonochemistry" Luche, J.-L., ed.,Plenum Press: New York, 1998, p.233)

9. Muralidharan, K. R.; Rowland-Goldsmith, M.; Lee, A. S.; Park, G.; Norman, A. W.; Henry, H. L.; Okamura, W. H. "Inhibitors of 25-Hydroxyvitamin D₃-1α-Hydroxylase: Thiavitamin D Analogs and Biological Evaluation", J. Steroid Biochem. Molec. Biol. 1997, 62, 73-78.

10. Adam Shih-Yuan Lee*, Hsiu-Chih Yeh and Jiun-Jie Shie "A Novel, Highly Efficient and Selective Desilylating Method for Trialkylsilyl Ethers", Tetrahedron Letters, 1998, 39, 5249-5252. (SCI, Citation Number = 40)

11. Adam Shih-Yuan Lee*, Feng-Yih Su and Yuan-Cheng Liao "A Simple and Efficient Hydrolyzing Method for Tetrahydropyranyl Ethers", Tetrahedron Letters, 1999, 40, 1323-1326. (SCI, Citation Number = 27)

12. Adam Shih-Yuan Lee* and Chen-Wen Wu "Stannyl-oriented Regioselective Allylation and its Application to the Synthesis of Silyl Misoprostol", Tetrahedron, 1999, 55, 12531-12542. (SCI, Citation Number = 15)

13. Adam Shih-Yuan Lee*, Li-Shin Lin "Synthsis of Allyl ketone via Lewis Acid Promoted Barbier-Type Reaction", Tetrahedron Letters, 2000, 41, 8803-8806. (SCI, Citation Number = 22)

14. Adam Shih-Yuan Lee*, Hui-Chun Yang and Feng-Yih Su "An Unprecedented and Highly Chemoselective Esterification Method", Tetrahedron Letters, 2001, 42, 301-303. (SCI, Citation Number = 21)

15. Adam Shih-Yuan Lee*, Yi-Jung Hu and Shu-Fang Chu "A Simple and Highly Efficient Deprotecting Method for Methoxymethyl and Methoxymethyl and Methoxyethoxymethyl Ethers and Methoxyethoxymethyl Esters", Tetrahedron, 2001, 57, 2121-2126. (SCI , Citation Number = 59)

16. Adam Shih-Yuan Lee* and Ming-Yi Chen “An Efficient and Highly Chemoselective Deprotecting Method for b-(Trimethylsilyl)ethoxymethy Ethers”, Journal of Organic Chemistry, 2002, 67, 1384-1387. (SCI , Citation Number = 20)

17. Ming-Yi Chen*, Kuo-Cheng Lu, Adam Shih-Yuan Lee*, Chun-Cheng Lin* “Chemoselective Deprotection of primary tert-butyldimethylsilyl ethers on carbohydrate molecules in the presence of secondary silyl ethers”, Tetrahedron Letters, 2002, 43, 2777-2780. (SCI, Citation Number = 28)

18. Adam Shih-Yuan Lee*, Yu-Ting Chang, Shu-Huei Wang and Shu-Fang Chu “Synthesis of 3,4-Disubstituted-a-methylene-g-lactone via Sonochemical Barbier-type Reaction”, Tetrahedron Letters, 2002, 43, 8489-8492. (SCI, Citation Number = 27)

19. Adam Shih-Yuan Lee* and Ming-Yi Chen “A Simple and Efficient Esterification Method”, Journal of Chinese Chemical Society, 2003, 50, 103-108. (SCI, Citation Number = 6)

20. Adam Shih-Yuan Lee*, Sui-Huei Wang, Yu-Ting Chang and Shu-Fang Chu “Synthesis of b-Amino and b-Methoxy Ketone by Lewis Acid Promoted b-Substitution of b,g-Unsaturated Ketone”, Synlett, 2003, 2359-2363. (SCI, Citation Number = 7)

21. Ming-Yi Chen, Laxmikant N. Patkar, Mi-Dan Jan, Adam Shih-Yuan Lee, Chun-Cheng Lin* “CBr₄-photoirradiation protocol for chemoselective deprotection of acid labile primary hydroxyl protecting groups”, Tetrahedron Letters, 2004, 45, 635-639. (SCI, Citation Number = 15)

22. Adam Shih-Yuan Lee*, Shu-Fang Chu, Su-Huei Wang and Yu-Ting Chang “Synthesis of Homopropargyl Alcohol via Sonochemical Barbier-type Reaction”, Tetrahedron Letters, 2004, 45, 1551-1553. (SCI, Citation Number = 25)

23. Adam Shih-Yuan Lee*, Chih-Chiang Wu, Li-Shin Lin, Hsiu-Fu Hsu “A Simple and Facile Carboxylation Method and Its Application for Synthesis of Liquid Crystals”, Synthesis, 2004, 4, 568-572. (SCI, Citation Number = 4)

24. Adam Shih-Yuan Lee*, Mei-Chun Lin, Shu-Huei Wang and Li-Shin Lin “A Mild Isomerization Reaction for b,g-Unsaturated Ketone to a,b-Unsaturated Ketone”, Journal of Chinese Chemical Society, 2004, 51(2), 371-376. (SCI, Citation Number = 1)

25. Chih-Kung Lee*, Shiming Lin, Adam Shih-Yuan Lee, Chii-Wann Lin, Jiun-Yan Wu, Shu-Sheng Lee, Wen-Hsin Hsiao, Shih-Jui Chen “From an Integrated Biochip Detection System to a Denfensive Weapon Against the SARS-CoV Virus: OBMorph, Materials Research Society Symposium Proceedings Series, 2004, 820, 249-260. (EI)

26. Ming-Yi Chen, Laxmikant N. Patkar, Kuo-Cheng Lu, Adam Shih-Yuan Lee, Chun-Cheng Lin* “Chemoselective deprotection of acid labile primary hydroxyl protecting groups under CBr₄-photoirradiation conditions”, Tetrahedron, 2004, 60, 11465-11476. (SCI, Citation Number = 11)

27. R.-Z. Hwang, L.-S. Huang, H.-S. Chang, C.-W. Wu, H.-C. Tien, S. Lin, A. S.-Y. Lee, “A Novel reusable nanomechanics based protein biosensor with electrical manipulation”, Proceedings of IEEE, The Eighteenth Annual International Conference on Micro Electro Mechanical Systems (MEMS), Miami Beach, Florida, USA, January, 2005, p.798-801. (EI, Citation Number = 1)

28. Hung-Yang Chen, Laxmikant N. Patkar, Shau-Hua Ueng, Chun-Cheng Lin*, Adam Shih-Yuan Lee* “Synthesis of b-Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines”, Synlett, 2005, 2035-2038. (SCI, Citation Number = 15)

29. Adam Shih-Yuan Lee* and Feng -Yih Su “Solvent-modulated chemoselective deprotections of trialkylsilyl esters and chemoselective esterifications”, Tetrahedron Letters, 2005, 46, 6305-6309. (SCI, Citation Number = 6)

30. Shiming Lin*, Chih-Kung Lee , Shih-Yuan Lee, Chuan-Liang Kao, Chii-Wann Lin, An-Bang Wang, Su-Ming Hsu and Long-Sun Huang, “Surface ultrastructure of SARS coronavirus revealed by atomic force microscopy”, Cellular Microbiology, 2005, 7(12), 1763-1770. (SCI, IF = 6.33, Citation Number = 14)

31. Adam Shih-Yuan Lee*, Yu-Ting Chang, Shu-Fang Chu, Ku-Wei Tsao “A facile and efficient synthesis of aryltriethoxysilanes via sonochemical Barbier-type reaction”, Tetrahedron Letters, 2006, 47, 7085-7087. (SCI, Citation Number = 14)

32. Shiming Lin*, Chih-Kung Lee, Yu-Ming Wang, Long-Sun Huang, Yun-Han Lin, Shih-Yuan Lee, Bor-Ching Sheu and Su-Ming Hsu, “Measurement of dimensions of pentagonal doughnut-shaped C-reactive protein using atomic force microscopy and dual polarisation interferometry”, Biosensors and Bioelectronics, 2006, 22(2), 323-327. (SCI, Citation Number = 20)

33. Shiming Lin*, Yun-Han Lin, Shih-Yuan Lee, Bor-Ching Sheu, Su-Ming Hsu and Chih-Kung Lee “Homopolyvalent antibody-antigen interaction kinetics studies using a dual polarization interferometric biosensor”, Biosensors and Bioelectronics, 2006, 22(5), 715-721. (SCI, Citation Number = 31)

34. Shiming Lin*, Adam Shih-Yuan Lee, Chih-Chen Lin and Chih-Kung Lee “Determination of Binding Constant and Stoichiometry for Antibody-Antigen Interaction with Surface Plasmon Resonance”, Current Proteomics, 2006, 3(4), 271-282. (SCI, Citation Number = 15)

35. Adam Shih-Yuan Lee*, Ku-Wei Tsao, Yu-Ting Chang, Shu-Fang Chu “A Facile Method for Synthesis of 5-Hydroxypentene via Sonochemical Barbier Reaction”, Journal of Chinese Chemical Society, 2007, 54(2), 519-524. (SCI, Citation Number = 4)

36. Adam Shih-Yuan Lee*, Ku-Wei Tsao, Yu-Ting Chang, Shu-Fang Chu “L-Proline Catalyzed Intramolecular Cyclization of 5-Hydroxypentene to b-Halogenated Tetrahydrofuran”, Tetrahedron Letters, 2007, 48, 6790-6793. (SCI, Citation Number = 7)

37. Ling-Chih Chien, Nan-Fu Chiu, Adam Shih-Yuan Lee, Lung-Jieh Yang, Yao-Joe Yang, Kuang-Chong Wu, Chih-Kung Lee, and Chii-Wann Lin* “Electrochemical Detection of High-Sensitivity C-Reactive Protein Based on Biomimic Design of Electroactive Nanoassembly Multilayers” Journal of Bionanoscience, 2007, 1, 44-50. (New Journal)

38. Ko, W. C.; Chen, J. L.; Wu, W. J.; Lee, Adam S.-Y.; Lee, C. K. “Effects of polar molecules on the electret properties of cyclic olefin copolymers (COC)” Proceedings - International Symposium on Electrets, 2008 IEEE, p.B0204. (EI)

39. Adam Shih-Yuan Lee*, Ge-An Chen, Yu-Ting Chang, Shu-Fang Chu “Cu(I) Halide Catalyzed Three-Component Coupling Reaction of Aldehyde, Pyrrolidine and Stannyl- and Silyl-acetylene”, Synlett, 2009, 441-446. (SCI, Citation Number = 2)

40. Adam Shih-Yuan Lee*, Ching-Hui Chung, Shu-Fang Chu, Yu-Ting Chang "Synthesis of Arylhydrazines by Reaction of Arylbromides with DEAD via Sonochemical Barbier Reaction", Journal of Chinese Chemical Society, 2009, 56, 202-205. (SCI)

41. Wen-Ching Ko, Chien-Kai Tseng, Ing-Yih Leu, Wen-Jong Wu, Adam Shih-Yuan Lee, Chih-Kung Lee* “Use of 2-(6-mercaptohexyl) malonic acid to adjust the morphology and electret properties of cyclic olefin copolymer and its application to flexible loudspeakers”, Smart Material and Structure, 2010, 19(5), 055007. (SCI, Citation Number = 9).

42. Adam Shih-Yuan Lee*, Yu-Ting Chang "Synthesis of cis-3,4-Diaryl a-methylene-g-butyrolactam via Sonochemical Barbier Reaction", Tetrahedron Letters, 2010, 51, 3800-3802. (SCI, Citation Number = 4)

43. Adam Shih-Yuan Lee*, Mei-Chun Lin, Chih-Chen Lin, Yu-Ting Chang "Me₃SiOTf Promoted Aza-Michael Addition Reaction of 1^o-Amide with a,b-Unsaturated Ketone", Journal of Chinese Chemical Society, 2010, 57(4B), 795-799. (SCI, Citation Number = 6)

44. Jhen-Gang Huang, Adam Shih-Yuan Lee, Shu-Fang Chu, Yun-Han Lin and Chii-Wann Lin, “INFLUENCE OF CONSTITUTION OF HYBRID FERROCENYL ALKANETHIOLS SELF-ASSEMBLED MONOLAYERS TO INTERFACIAL CHARACTERISTICS ON GOLD SURFACE” Biomedical Engineering: Applications, Basis and Communications, 2010, 22(1), 25–31. (SCI)

45. Bor-Ching Sheu*, Yun-Han Lin, Chih-Chen Lin, Adam Shih-Yuan Lee, Wen-Chun Chang, Jung-Hsin Wu, Jui-Chang Tsai, Shiming Lin*, “Significance of the pH-induced conformational changes in the structure of C-reactive protein measured by dual polarization interferometry”, Biosensors and Bioelectronics, 2010, 26(2), 822-827. (SCI, Citation Number = 4)

46. Bor-Ching Sheu*, Chih-Chen Lin, Ying-Hsien Fu, Shih-Yuan Lee, Hsin-Chih Lai, Rung-Shin Wu, Chih-Hao Liu, Jui-Chang Tsai, Shiming Lin “Unraveling the Role of the rssC Gene of Serratia marcescens by Atomic Force Microscopy”, Microscopy and Microanalysis, 2010, 16(6), 755-763. (SCI)

47. Ching-Sung Chen, Ku-Ning Chang, Ying-Hua Chen, Chih-Kung Lee, Bryan Yong-Jay Lee, Adam Shih-Yuan Lee, ”Development of a label-free impedance biosensor for detection of antibody–antigen interactions based on a novel conductive linker”, Biosensors and Bioelectronics, 2011, 26(6), 3072-3076. (SCI, Citation Number = 7)

48. Adam Shih-Yuan Lee*, Pin-Lung Chen, Yu-Ting Chang, Heng-Tser Tsai “FeCl₃ Catalyzed Barbier Homocoupling Reaction for Synthesis of Symmetric Biaryls”, Journal of Chinese Chemical Society, 2012, 59(3), 452-454. (SCI)

49. Adam Shih-Yuan Lee*, Li-Shin Lin, Yu-Ting Chang “Synthesis of cis-2,6-Tetrahydropyran-4-one via Diastereoselectively Intramolecular Cyclization of b-Hydroxy Allyl Ketone”, Tetrahedron, 2012, 68(20), 3915-3919. (SCI, Citation Number = 3)

50. Adam Shih-Yuan Lee*, Ching-Hui Chung, Yu-Ting Chang and Pin-Lung Chen “L-Proline Catalyzed Condensation Reaction of Aldehyde or Carboxylic Acid with 2-Aminothiophenol under Solvent-Free and Microwave Irradiation”, Journal of Applied Science and Engineering, 2012, 15(3), 311-315. (EI)

51. Adam Shih-Yuan Lee*, Yu-Ting Chang and Feng-Yi Su "Chemoselective Synthesis of β-Amino Ester or β-Lactam via Sonochemical Reformatsky Reaction", Journal of Chinese Chemical Society, 2014, 61(2), 290-294. (SCI)

52. Adam Shih-Yuan Lee*, Shu-Huei Wang, Yu-Ting Chang " Synthesis of β-Haloketones by β-Addition Reactions of α,β-Unsaturated Ketones with BX3 (X=Br, Cl) as Halide Source", Journal of Chinese Chemical Society, 2014, 61(3), 364-368. (SCI)

53. Adam Shih-Yuan Lee*, Yu-Chi Wu, Yu-Ting Chang and Bo-Cheng Wang "Synthesis of 3-Substituted Indole by AlCl₃ Promoted Reaction of α,β-Unsaturated Ketone with Indole", Research on Chemical Intermediates, 2014, 40(6), 2277-2285. (SCI)

54. Pei-I Tsai ; Shu-Sheng Lee ; Shin-Ting Chou ; Yu-Ting Chang ; Adam Shih-Yuan Lee ; C. K. Lee “Integrating SPR-ellipsometry and electrochemical measurements for performance evaluation of label-free thiophene-based biosensor” Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8933, 89330H (March 5, 2014).

55. P.I. Tsai, S.S. Lee, S.T. Chou, C.M. Jan, Y.T. Chang, A.S.Y. Lee, C.K. Lee* "A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis", Thin Solid Film, 2014, 571,473-477. (SCI)

56. Chih-Hsin Chen*, Yi-Cheng Lin , Hao-Hsiang Chang , and Adam Shih-Yuan Lee* "Ligand-Doped Liquid Crystal Sensor System for Detecting Mercuric Ion in Aqueous Solutions", Anal. Chem., 2015, 87, 4546-4551. (SCI, IF= 5.64)

57. Adam Shih-Yuan Lee*, Szu-Huio Ma Lee, Yu-Ting Chang "Microwave Assisted Synthesis of Dihydropyrrole by AgOAc Catalyzed Intramolecular Cyclization Reaction of Homopropargyl amine", Research on Chemical Intermediates, 2016, In Press. (SCI)

技術報告

1. 朱淑芳；李舒昇；薛順成；李世光；林啟萬；林世明；李世元；李世仁 “生物晶片技術現況-從蛋白質晶片儀暨蛋白微陣列晶片談起” , 新電子科技雜誌, 2002, 2, 180-185.

2. 李舒昇；薛順成；吳俊彥；李世光；林啟萬；林世明；朱淑芳；蕭亦何；邱志鵬；李世元 “多工光電醫學檢測儀系統之開發”, 光訊, 行政院國科會光電小組, 2002, 九十四期, 16-21.

3. 韓謝忱；朱淑芳；李世元；林世明 “生物感測晶片界面”, 科學月刊, 2002, 33(11), 941-946.

4. 李世光；林世明；李世元；蘇慶琅；歐芳序 “抗煞一號背後的奈米生物科技” , 科學月刊, 2003, 34(8), 713-717.

5. Chih-Kung Lee, Wen-Hsin Hsiao, Shiming Lin, Adam Shih-Yuan Lee “Nano-mechanics of a SARS Denaturing Agent”, 第二十屆機械工程研討會論文集,December, 2003.(EI)

6. 林志成、李世元、林世明“生物巨分子相互作用與形變奈米量測技術” 中華民國自動化科技協會會刊, 2005, 12, 45-50.

7. 王裕銘、陳吉良、黃榮山、李世元、李世光、林世明“等溫滴定熱量儀：蛋白質形變、動力學暨結合常數奈米熱量測”, 科儀新知,2005,27卷第1期, 67-72.

8. 林啟萬、呂慧歆、林勁戎、蘇明啟、李世光、林世明、李世元“表面電漿子共振在生醫感測之調變設計與藥物篩選應用研發”, 微系統暨奈米科技協會會刊, 17, p.18-27, Jun. 2007.

9. 林志成、林世明、李世元 “奈米量測技術－原子力顯微鏡在生物分子上之應用”,化學, 2009, 67卷第1期, 83-91.

10.李世元“防疫最前線-化學人的戰爭”,泰宇化學專刊, 2009, 1-8.

11.李世光、郭宜靜、黎凱強、張谷寧、陳菁松、陳盈樺、李世元、陳品龍 “以導電連結分子為基礎之免標定阻抗式生物感測器”,化學,2011, 67卷第3期, 193-198.

專書及專書論文

1. 李世光；林世明；李世元；林啟萬；許世明 “抗SARS消毒噴劑”,第七章奈米生物技術, p.343-346,台灣奈米科技-從2004到嚮往的大未來,工業技術研究院.

2. 呂學士、李世元、林啟萬、張道治、莊晴光、闕志達、蘇育德、蕭子健、蔡佩漪、陳慧玲、鄭珉芳、楊雅棻,”EU 1ST 2004 Taiwan e-Health”.

專利

1. 李世元、張皓翔、朱淑芳、張瑀庭 “用於重金屬檢測之重金屬感應分子及其製造方法” 中華民國專利 I364537 (2012.05.21)

2. Chih-Kung Lee; Adam Shih-Yuan Lee; Ching-Sung Chen; Ku-Ning Chang; Ying-Hua Chen; Bryan Yong-Jay Lee “LINKER, IMPEDANCE BIOCHIP, AND METHOD OF QUANTITATIVELY DETECTING TARGET ANALYTE IN FLUID SAMPLE USING THE BIOCHIP” US 2012/0067742 A1 (Mar. 22, 2012)

3. Shi-Ming Lin; Chih-Kung Lee; Shih-Yuan Lee; Jim-Tong Hong;Ming-Chu Cheng; Chih-Chen Lin; Rong-Sin Wu, Shu-Fang Chu; Yu-Ting Chang,Wen-Ching Ko “COMPOUND FOR INACTIVATING VIRUSES AND BACTERIA AND METHOD OF MAKING SAME” US 8,110,605 B2 (Feb. 7, 2012)

4. Chi-Wan Lin; Chih-Kung Lee; Kuang-Chong Wu; Shi-Ming Lin; Shih-Yuan Lee; Fu-Shan Jaw; Chern-Lin Chen; U Lei, Long-Sun Huang; Shey-Shi Lu; Phone Lin; Jia-Yush Yen; Yao-Joe Yang; Lung-Jieh Yang; Wen-Ping Shih; Nan-Fu Chiu “WIRELESS MONITORING BIO-DIAGNOSIS SYSTEM” US Patent, US 2010/0274101 A1 (Oct. 28, 2010)

5. Shiming Lin; Shih-Yuan Lee; Bor-ching Shue; Chih-Chen Lin; Panchien Lin “ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR HAVING CONDUCTIVITY PROMOTION MOLECULES”, US Patent, US 2010/0172800 A1 (Jul. 8, 2010)

6. Shiming Lin; Shih-Yuan Lee; Bor-ching Shue; Chih-Chen Lin; Panchien Lin “ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT METHOD”, US Patent, US 2010/0171487 A1 (Jul. 8, 2010).

7. Shiming Lin; Shih-Yuan Lee; Bor-ching Shue; Chih-Chen Lin; Panchien Lin “ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT METHOD”, US Patent, US 2010/0170792 A1 (Jul. 8, 2010)

8. Shiming Lin; Shih-Yuan Lee; Bor-ching Shue; Chih-Chen Lin; Panchien Lin “ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT METHOD”, US Patent, US 2010/0170788 A1 (Jul. 8, 2010)

9. Long Sun Huang; Chih-Kung Lee; Shih-Yuan Lee; Kuang-Chong Wu; Yi Kuang Yen “MICRO-SENSOR FOR SENSING CHEMICAL SUBSTANCE”, US Patent, US 7,730,767 B2 (Jun. 8, 2010)

10. Shih-Yuan Lee; Chih-Kung Lee; Wen-Ching Ko; Jia-Lun Chen; Ing Yih Leu; Wen-Hsin Hsiao; Wen-Jong Wu "ELECTRET MATERIALS, E LECTRET SPEAKERS, AND METHODS OF MANUFACTURING THE SAME", US Patent US 2009/0245547 A1 (Oct. 1, 2009)

11. 李世光、林世明、李世元、朱淑芳、蕭文欣, "一種破壞冠狀病毒治病性之化學原料" 中華民國專利I304338 (2008/12/21)

12. 李世元、朱淑芳、張瑀庭、王淑惠、李世光、林世明、林啟萬、蕭文欣, “氫氧基烷酸化合物及正-溴基烷酸之合成方法” 中華民國專利I302529 (2008/11/1)

13. 林世明、李世光、李世元、林頒千、陳吉良、林雲漢、林啟萬、許世明,”具有共價鍵結定錨化合物之分子探針晶片” 中華民國專利 I270673 (2007/1/17)

14. Chih Kung Lee; Shiming Lin; Shih Yuan Lee; Shu Fang Chu; Wen Hsin Hsiao; Lung tan Shiang "SUBSTANCES FOR BREAKING DOWN CONFORMATION OF MICROBES", US Patent US 2005/0014830 A1 (Jan. 20, 2005)

15. Shih-Yuan Lee and Hsiu-Chih Yeh "Process for Preparing Optically Active Allylic Alcohol Derivatives", US Patent 5,989,900 (Nov. 23, 1999).