期刊論文
1. Ding, Y. C.; Chu, Y. C.; Chang, C.-H; Liang, J.-H.; Chen*, J.-J., Shih*, T.-L"Synthesis of 2-(pyridylvinyl)chromen-4-ones and their N -oxide analogs for assessment of their biological activities as anticancer agents" Arch. Pharm. 2023 (accept)
2.Chen, Y.-X; Chang, C.-H.; Li, C.-W.; Chen,* J.-J.;Shih,* T.-L."Design, synthesis and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents" J. Chin. Chem. Soc. 2023, 70, 1924-1936 (cover feature)
3. Chen, Y.-C.; Chu Y.-C.; Li, C.W.; Chen,* J.-J.; Shih,* T.-L. "Synthesis and evaluation of 6-amino-2-styrylchromones as anticancer agents" ChemistrySelect 2023, 8, e202300685
4. Chen, Y.-C.; Li, C.-W.; Chen,* J.-J.; Shih,* T.-L. “Synthesis of selenophene-based chalcone analogues and assessment of their biological activity as anti-cancer agents” Arch. Pharm. 2023, 356, e2200486.
5. Cheng, Y.-J.; Li, C.-W.; Kuo, C.-L.; Shih,* T.-L.; Chen,* J.-J. “Improved Synthesis of Asymmetric Curcuminoids and Their Assessment as Antioxidants” Molecules 2022, 27, 2547.
6. Wang, R.-Y.; Li, C.-W.; Cho, S.-T.; Chang, C-H.; Chen,* J.-J.; Shih,* T.-L. “Synthesis of cinnamils and quinoxalines and their biological evaluation as anti-cancer agents” Arch. Pharm. 2022, 355, 2100448.
7. Shih, T.-L.; Lin, K.-H.; Chen, R.-J.; Chen, T.-Y.; Kao, W.-T.; Liu, J.-W.; Wang, H.-H.; Peng, H.-Y.; Sun, Y.-Y.; Lu, W.-J.* “A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI” J. Cell. Mol. Med. 2021, 25, 9434-9446.
8. Tsai, H. Y.; Huang, Y.-T.; Kuo, C.-L.; Kuo, C.-J.; Hu,* A.; Chen,* J.-J.; Shih,* T.-L. “A case study of the iodine-mediated cyclization of C2’-OH- and C2-OH-chalcones toward the synthesis of flavones. Reinvestigation of the mechanisms” J. Chin. Chem. Soc. 2021, 68, 1334-1338.
9. Hung, S.-J.; Hong, Y.-A.; Lin, K.-Y.; Hua, Y.-W.; Kuo, C.-J.; Hu, A.; Shih,* T.-L.; Chen,* H.-P.* “Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids” Int. J. Mol. Sci. 2020, 21, 9024.
10. Tung, C.-H.; Lu, Y.-T.; Kao, W.-T.; Liu, J.-W.; Lai, Y.-H.; Jiang, S.-J.; Chen,* H.-P.; Shih,* T.-L. “Discovery of a more potent anti-cancer agent than C4-benzazole 1,8-naphthalimide derivatives against murine melanoma” J. Chin. Chem. Soc. 2020, 67, 1254-1262. (Cover figure).
11. Wang, R.-Y.; Kao, W.-T.; Shih,* T.-L. “Synthesis of selenium-containing biindolyls and their Diels-Alder reaction toward the synthesis of hetero-annulated[a]- and [c]-carbazoles” J. Chin. Chem. Soc. 2020, 67, 829-837.
12. Tsai, M.-C.; Huang, P. Y.; Syu, L. S.; Shih,* T.-L. “Synthesis of novel isoquinolino[5,4-ab]phenanthridine derivatives via Pictet-Spengler reaction” Synthesis 2019, 51, 1377-1382.
13. Yang, M.-Y.; Khine, A. A.; Liu, J.-W.; Cheng, H.-C.; Hu*, A.; Chen*, H.-P.; Shih*, T.-L. "Resolution of Isoborneol and its Isomers by GC/MS to Identify “Synthetic” and “Semi-synthetic” Borneol Products." Chirality 2018, 30, 1233-1239.
14. Shih, T.-L.; Liu, M.-H.; Li, C.-W.; Kuo*, C.-F. “Halo-Substituted Chalcones and Azachalcones-Inhibited, Lipopolysaccharited-Stimulated, Pro-Inflammatory Responses through the TLR4-Mediated Pathway” Molecules 2018, 23, 597.
15. Ho, T.-J.; Hung, C.-C.; Shih, T.-L.; Yiin, L.-M.; Chen, H.-P “Investigation of borneols sold in Taiwan by chiral gas chromatography” J. Food. Drug. Anal. 2018, 26, 348-352.
16. Li, C.-W.; Shen, T.-H; Shih*, T.-L. “Reinvestigation of synthesis of halo-substituted 3-phenyl-1-(2-pyridyl)-2-propen-1-ones (azachalcones). A tandem reaction for formation of penta-substituted cyclohexanols” Tetrahedron 2017, 73, 4644-4652.
17. Lu, Y.-T.; Chen, T.-L.; Chang, K.-S.; Chang, C.-M.; Wei, T.-Y.; Liu, J.-W.; Hsiao, C.-A.; Shih*, T.-L. “Synthesis of novel C4-benzazole naphthalimide derivatives with potentanti-tumor properties against murine melanoma” Bioorg. Med. Chem. 2017, 25, 789-794.
18. Chen, Y.-R.; Cho, Y. C.; Shih*, T.-L. “Reinvestigation of ortho-amidoacetophenones’ cyclization mediated by trimethylsilyl trifluoromethanesulfonate. The Lewis-acid-assisted and Brønsted-acid-catalyzed reaction” Tetrahedron 2016, 72, 2006-2011.
19. Shih*, T.-L.; Liao, W.-Y.; Yen, W.-C. “Regioselective fluorination in synthesis of deoxyfluoro quercitols from D-(-)-quinic acid” Tetrahedron 2014, 70, 9621-9627.
20. Shih*, T.-L.; Chou, C.-E.; Liao, W.-Y.; Hsiao, C.-A. “Copper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids” Tetrahedron 2014, 70, 3657-3664.
21. Tai, C.-K.; Yeh, P.-L.; Wu, Y.-S.; Shih*, T.-L.; Wang*, B.-C. “Theoretical investigation of conformational stabilities and 13C NMR chemical shifts of a seven-membered ring thiosugar, (3R,4R,5R,7S)-7-(hydroxymethyl)thiepane-3,4,5-triol” J. Mol. Stru. 2014, 1068, 84-93.
22. Shih*, T.-L.; Gao, W.-L. “The First Synthesis of 7-(Hydroxymethyl)thiepane-3,4,5-triols from D-(-)-Quinic Acid” Tetrahedron 2013, 69, 1897-1903.
23 Chen, H.-H.; Lin, H.-A.; Lai, Y.-H.; Lin, S.-Y.; Chiang, C.-H.; Hsu*, H.-F.; Shih*, T.-L.; Lee, J.-J.; Lai, C.-C.; Kuo, T.-S.; “Enantiotropic Nematics From Cross-Like 1,2,4,5-Tetrakis(4-Alkyl-4-Ethynylbiphenyl)Benzenes And Their Biaxiality Studies” Chem. Eur. J. 2012, 18, 9543-9551.
24. Shih*, T.-L.; Hsiao, C.-A.; Lin, Z.-Y.; Chen*, Y.-H. “An Alternative Synthesis of 3’,4’-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae” Molecules 2012, 17, 8206-8216.
25. Chen, H.-H.; Lin, H.-A.; Chien, S.-C.; Wang, T.-H.; Hsu*, H.-F.; Shih*, T.-L.; Wu, C. “Single-component room-temperature discotic nematic liquid crystals formed by introducing an attraction-enhancing inplane protrusion onto the hexa(phenylethynyl)benzene core” J. Mater. Chem. 2012, 22, 12718-12722.
26. Yeh, P.-L.; Tai, C.-K.; Shih*, T.-L.; Hsiao, H.-L.; Wang*, B.-C. “Conformational analysis of a seven-membered ring azasugar, (3R,4R,6S)-trihydroxyazepane: Comparison of GIAO calculation andexperimental NMR spectra on 13C chemical shifts“ J. Mol. Stru. 2012, 1018, 64-71.
27. Shih*, T.-L.; Yang, S.-Y. “Regioselectivity in the Ring Opening of Epoxide for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid” Molecules 2012, 17, 4498-4507. |
28. Chen*, Y.-H.; Yang, Z.-S.; Wen, C.-C.; Chang, Y.-S.; Wang*, B.-C.; Hsiao, C.-A.; Shih*, T.-L. “Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae” Food Chemistry. 2012, 134, 717-724.
29. Shih*, T.-L.; Liang, M.-C.; Wu, K.-D.; Lin*, C.-H “Synthesis of Polyhydroxy 7- and N-Alkyl-Azepanes as potent Glycosidase Inhibitors” Carbohydr. Res. 2011, 346, 183-190.
30. Shih*, T.-L.; Li, H.-Y.; Ke, M.-S.; Kuo, W.-S. “Synthesis of a New Family of Aminocyclitols from D-(-)- Quinic Acid” Synth. Commun. 2008, 38, 4139-4149.
31. Shih*, T.-L.; Yang, R.-Y.; Li, S.-T.; Chiang, C.-F.; Lin*, C.-H. ''Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from D-(-)-Quinic Acid as Potent Glycosidase Inhibitors " J. Org. Chem. 2007, 72, 4258-4261.
32. Shih*, T.-L.; Fang, Y.-J. ''An expeditious synthesis of new 3,4,6-trihydroxythiepanes from D-(-)-quinic acid'' Synth. Commun. 2007, 37, 3337-3349.
33. Shih*, T.-L.; Lin, Y.-L. ''Epoxidation of protected 1,4,5-cyclohex-2-ene-triols and their acid hydrolysis to synthesize quercitols from D-(-)-quinic acid" Synth. Commun. 2005, 35, 1809-1817.
34. Shih*, T.-L.; Lin, Y. -L.; Kuo, W. -S. "Highly stereoselective and stereospecific syntheses of a variety of quercitols from D-(-)-quinic acid" Tetrahedron 2005, 61, 1919-1924.
35. Shih*, T.-L.; Kuo, W.-S.; Lin, Y.-L. "A facile synthesis of a new trihydorxy piperidine derivative and (+)-proto-quercitol from D-(-)-quinic acid" Tetrahedron Lett. 2004, 45, 5751-5754.
36. Shih*, T.-L.; Tseng, J.-H. "An efficient synthesis of L-allono-1,4-lactone from 2,3;5,6-di-o-isopropylidene-D-mannono-1,4-lactone" Tetrahedron Lett. 2004, 45, 1789-1791.
37. Paquette, L.A.; Zeng, Q.; Wang, H.-L.; Shih, T.-L.“From Carbohydrates to the Discovery of Pronounced Heteroatomic Effects on Anionically Accelerated [3,3]-Sigmatropic Rearrangements” Eur. J. Org. Chem. 2000, 2187.
38. Shih*, T.-L.; Wu*, S.-H.“ Efficient Syntheses of (-)-Shikimate and (-)-Quinate 3-Phosphated via Trans Vicinal Diol Protection with 2,2,3,3-Tetramethoxy Butane(TMB)of Shikimic and Quinic Acid ” Tetrahedron Lett. 2000, 41, 2957.
39. Shih*, T.-L.; Chen, M.-C.; Wu*, S.-H. “Chemoenzymatic Preparation of 4-O-Acetyl Sialic Acid Derivative” Tetrahedron Lett. 2000, 41, 7921.
40. Paquette, L. A.; Shih, T.-L.; Zeng, Q.; Hofferberth, J. E. ”Synthesis of Stereodefined Z-Vinyl Iodides from Carbohydrates as a Prelude to C/D Ring Assembly in Taxanes” Tetrahedron Lett. 1999, 40, 3519.
41. Paquette, L. A.; Wang, H.-L.; Zeng, Q.; Shih, T.-L.”Heteroatomic Modulation of Oxyanionic Cope Rearrangement Rates. Consequences on Competing Nucleophilic Cleavage of an Oxetane Ring in Precursors to Paclitaxel” J. Org. Chem. 1998, 63, 6432.
42. Andrus, M. B.; Shih, T.-L “Synthesis of Tuckolide, a New Cholesterol Biosynthesis Inhibitor” J. Org. Chem. 1996, 61, 8780.
43. Li, C.; Shih, T.-L.; Jeong, J. U.; Arasappan, A.; Fuchs, P. L. ”The Use of Tetramethylguanidinium Azide in Non-halogenated Solvents Avoids Potential Explosion Hazards” Tetrahedron Lett. 1994, 35, 264.
44. Wu, C.-L; Huang, C.-D.; Shih, T.-L.“A Sesquiterpene Oxide of a Novel Skeleton From the Liverwort Plagiochila peculiaris” Tetrahedron Lett. 1993, 34, 4855.
45. Johnson, S. C.; Dahl, J.; Shih, T.-L.; Schedler, D. J. A.; Anderson, L.; Benjamin, T. L.; Baker, D. C.“Synthesis and Evaluation of 3-Modified 1D-Myo-Inositols as Inhibitors and Substrates of Phosphatidylinositol Synthase and Inhibitors of Myo-Inositol Uptake by Cells” J. Med. Chem. 1993, 36, 3628.
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