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陳曜鴻(Yau-Hung Chen)

發育生物學、癌症生物學、毒理學、基因轉殖、化學生物


2010-至今 淡江大學化學系教授
2009-2010 淡江大學化學系副教授
2007-2009 淡江大學生命科學研究所副教授
2004-2007 淡江大學生命科學研究所助理教授
2003-2004 台灣大學特約博士後研究員
2002-2003 美國奧勒岡大學博士後訪問學者
2001-2003 台灣大學博士後研究員
1997-2001 台灣大學博士
1995-1997 台灣大學碩士
1989-1993 台灣大學學士

2010- present Tamkang University, Professor
2007-2010 Tamkang University, Associate Professor
2004-2007 Tamkang University, Assistant Professor
2002-2003 University of Oregon , Visiting Scholar
2001-2004 National Taiwan University, Post-doctor
1997-2001 National Taiwan University, PhD
1995-1997 National Taiwan University, MS
1989-1993 National Taiwan University, BS


陳曜鴻



聯絡電話:(02) 2621-5656 ext.3009 傳真:

研究室:C108

實驗室:C114、C115

E-mail: yauhung@mail.tku.edu.tw

研究專長及興趣

1.頭部肌肉與軟骨發育之分子機制探討

2.建立人類基底細胞癌(basal cell carcinoma)之魚類模式

3.抗癌金屬藥物與中草藥之篩選

4.環境毒物對於胚胎發育之影響

 

實驗室合照

 

 

 

研究內容簡介

基底細胞癌(basal cell carcinoma)

基底細胞癌是最常見的皮膚癌,大約佔所有皮膚惡性腫瘤的80%以上,好發於頭臉、頸和手部。這種癌症生長緩慢而通常不會轉移到其他部位,但是若沒有處置,會局部破壞及侵犯組織,例如骨頭及神經。在基因層次方面的研究,基底細胞癌其主要成因為sonic hedgehog (shh)訊息傳遞路徑過度活化所導致的癌症。在動物模式的實驗中,以小鼠的研究為例,Oro等人(1997)將被keratin啟動子所驅動的shh基因利用基因轉殖的技術,讓shh基因專一性地在表皮組織過度表現,結果這些基因轉殖小鼠,呈現出多趾(polydactyly)、脊柱裂開(spina bifida)與一些典型的基底細胞癌的症狀,成功地重建基底細胞癌的動物模式。而這種品系的小鼠,在出生前即死亡,並不適合用來當成篩選抗癌藥物的工具。因此,我們建立了基底細胞癌的基因轉殖斑馬魚品系,以便用來開發抗腫瘤新藥。

 

斑馬魚當成藥物篩選平台之優點

斑馬魚(zebrafish, Danio rerio)是一種小型觀賞魚,成魚體長約3公分,好養又便宜,體積小,一般的家用一尺水族箱大約可養20隻左右,可大大地降低養殖成本。這類小型魚種擁有卵的數量多(每週可產100-300顆卵),卵徑大而且透明,沒有產卵期的限制,體外授精,整個胚胎發育及器官形成的過程都可以直接在顯微鏡下觀察,基因轉殖操作簡單、成熟期又只有2-3個月等優點。因此,斑馬魚已成為研究癌症、心血管疾病、器官發育、脊椎動物胚胎發育、神經發育、細胞凋亡的重要模式,在藥物毒性的篩檢也扮演重要角色。斑馬魚在抗癌藥物的篩選上最大的好處是生長週期短,可以很快速、很有效率的評估療效,並且飼養成本只有小白鼠的百分之一至千分之一,非常適合藥物的篩選。

cmlsboneToxicolSci 
 

專業服務

(1) 國際期刊審稿委員(Reviewer): Journal of Fish Biology, Photochemistry and Photobiology, Food and Chemical Toxicology, Environmental Toxicology, Journal of Peptide Science, Expert Opinion on Drug Discovery

(2) 國際期刊編審委員(Editorial Board Member): Biotechnology Research International, International Journal of BiotechScience

(3) 國際期刊副主編(Associate Editor): International Journal of Biotechnology Applications
 

2016-present

(1) Chen YH*, Chen YJ, Chou CY, Wen CC, Cheng CC* (2016) UV-protective activities of pineapple leaves extract in zebrafish embryos. Research on Chemical Intermediates (in press)

(2) Chang CF, Hsu LS, Weng CY, Chen CK, Wang SY, Chou YH, Liu YY, Yuan ZX, Huang WY, Lin H, Chen YH, Tsai JN* (2016) STT3B-dependent N-glycosylation of human R-spondin 1 is required for efficient secretion but not for its heparin binding affinity. International Journal of Molecular Sciences 17: 937.

(3) Yan D, Ni LK, Chen HL, Chen LC, Chen YH*, Cheng CC* (2016) Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo. Bioorganic & Medicinal Chemistry Letters 26: 774-777.

(4) Klionsky DJ*, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, (….), Chen YH, et al., (2016) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12: 1-222.

 

2011-2015

(5) Chen YH*, Chang CY, Chang CF, Chen PC, Lee YT, Chern CY*, Tsai JN* (2015) Pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo. Molecules 20: 12512-12524.

(6) Chen YH*, Chang CF, Lai YY, Sun CY, Ding YJ, Tsai JN* (2015) von Hippel–Lindau gene plays a role during zebrafish pronephros development. In Vitro Cellular & Developmental Biology-Animal 51: 1023-1032.

(7) Chen YH, Chou CY, Sun CY* (2015) Impairment of cellular distribution and stability of erythropoietin receptor by direct targeting of aristolochic acid. Toxicological Sciences 147: 246-254. (cover image)

(8) Ding YJ, Wang BC, Wen CC, Sun CY, Lee HH, Lee FP, Yang LL*, Chen YH* (2015) Evaluation of the teratogenic effects of three traditional Chinese medicines, Si Jun Zi Tang, Liu Jun Zi Tang and Shenling Baizhu San, during zebrafish pronephros development. Journal of Toxicologic Pathology 28: 141-149.

(9) Wu YC, Chang CY, Kao A, Hsi B, Chen YH*, Wang IJ* (2015) Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity. PLoS One 10: e0126750.

(10) Wu HJ, Fong TH, Chen SL, Wei JC, Wang IJ, Wen CC, Chang CY, Chen XG, Chen WY, Chen HM, Horng JL, Wang YH*, Chen YH* (2015) Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment. Journal of Applied Toxicology 35: 287-294.

(11) Sun CY, Young GH, Hsieh YT, Chen YH, Wu MS, Wu VC, Lee JH, Lee CC* (2015) Protein-bound uremic toxins induce tissue remodeling by targeting the EGF receptor. Journal of the American Society of Nephrology 26: 281-290.

(12) Ding YJ, Sun CY, Wen CC, Chen YH* (2015) Nephroprotective role of resveratrol and ursolic acid in aristolochic acid intoxicated zebrafish. Toxins 7: 97-109.

(13) Chang WN, Lee GH, Kao TT, Lin CY, Hsiao TH, Tsai JN, Chen BH, Chen YH, Wu HR, Tsai HJ, Fu TF* (2014) Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Biochimica et Biophysica Acta-General Subjects 1840: 2340-2350.

(14) Chen YH*, Lee YT, Wen CC, Chen YC, Chen YJ* (2014) Modeling pegylated liposomal doxorubicin-induced hand-foot syndrome and intestinal mucositis in zebrafish. OncoTargets and Therapy 7: 1169-1175.

(15) Lo KC, Sun CY, Ding YJ, Tsai JN, Chang KP, Wen YE, Chang WL, Chang SC, Chang MF, Wang YH, Chen YH* (2014) Nephrotoxicity assessments of benzo(a)pyrene during zebrafish embryogenesis. Research on Chemical Intermediates 40: 2177-2185.

(16) Cheng CC*, Chou CY, Chang YC, Wang HW, Wen CC, Chen YH* (2014) Protective role of comfrey leave extracts on UV-induced zebrafish fin damage. Journal of Toxicologic Pathology 27: 115-121.

(17) Chen XG, Wang YH, Wen CC, Chen YH* (2014) Overdose of D-serine induces movement disorder and neuromuscular changes of zebrafish larvae. Journal of Toxicologic Pathology 27: 19-24.

(18) Lee YT, Fong TH, Chen HM, Chang CY, Wang YH, Chern CY*, Chen YH* (2014) Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model. Molecules 19: 641-650.

(19) Chen YH, Pai CW, Huang SW, Chang SN, Lin LY, Chiang FT, Lin JL, Hwang JJ, Tsai CT* (2013) Inactivation of myosin binding protein C homolog in zebrafish as a model for human cardiac hypertrophy and diastolic dysfunction. Journal of the American Heart Association 2: e000231.

(20) Ding YJ, Chen XG, Chen YH* (2013) Molecular structure and developmental expression of two zebrafish ankylosis progressive homolog (ankh) genes, ankha and ankhb. Russian Journal of Developmental Biology 44: 307-313.

(21) Lin MD*, Lee HT, Wang SC, Lee HR, Hsien HL, Cheng KW, Chang YD, Huang ML, Yu JK*, Chen YH* (2013) Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. BMC Developmental Biology 13:18. (image highlight)

(22) Chen YH*, Wang WH, Wang YH, Lin ZY, Wen CC, Chern CY* (2013) Evaluation of anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model. Molecules 18: 2052-2060.

(23) Wu CG, Cheng SC, Chen SC, Li JY, Fang YH, Chen YH, Chou CY* (2013) Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease. Acta Crystallographica Section D-Biological Crystallography 69: 747-755.

(24) Tsai IT, Chen YH, Chen YH*, Wang YH* (2013) Amikacin-induced fin reduction is mediated by autophagy. Journal of Toxicologic Pathology 26: 79-82.

(25) Wu YC, Liu CY, Chen YH, Chen RF, Huang CJ, Wang IJ* (2012) Blood vessel epicardial substance (BVES) regulates epidermal tight junction integrity through atypical protein kinase C. Journal of Biological Chemistry 287: 39887-39897.

(26) Shih TL*, Hsiao CA, Lin ZY, Chen YH* (2012) An alternative synthesis of 3’,4’-Diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. Molecules 17: 8206-8216.

(27) Jhou YR, Chiou CH, Ni LK, Chen LC, Chen YH, Cheng CC* (2012) Cellular uptake of a polypyridyl ruthenium complex revealed using a fluorescent rhodamine-modified ruthenium complex. Journal of the Chinese Chemical Society 59: 1053-1057.

(28) Ding YJ, Chen YH* (2012) Developmental nephrotoxicity of aristolochic acid in a zebrafish model. Toxicology and Applied Pharmacology 261: 59-65.

(29) Wu CK, Huang YT, Lee JK, Chiang LT, Chiang FT, Huang SW, Lin JL, Tseng CD, Chen YH*, Tsai CT* (2012) Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure. PLoS One 7: e35242.

(30) Chen YH*, Yang ZS, Wen CC, Chang YS, Wang PC*, Hsiao CA, Shih TL* (2012) Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. Food Chemistry 134: 717-724.

(31) Yeh CH, Liao YF, Chang CY, Tsai JN, Wang YH, Cheng CC, Wen CC, Chen YH* (2012) Caffeine treatment disturbs the angiogenesis of zebrafish larvae. Drug and Chemical Toxicology 35: 361-365.

(32) Tsai IT, Yang ZS, Lin ZY, Wen CC, Cheng CC, Chen YH* (2012) Flavone is efficient to protect zebrafish fins from UV-induced damages. Drug and Chemical Toxicology 35: 341-346.

(33) Chen YH, Tsai IT, Wen CC, Wang YH, Cheng CC, Hu SC, Chen YH* (2012) Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos. Toxicology Mechanisms and Methods 22: 151-158.

(34) Lee GH, Chang MY, Hsu CH, Chen YH* (2011) Essential roles of basic helix-loop-helix transcription factors, Capsulin and Musculin, during craniofacial myogenesis of zebrafish. Cellular and Molecular Life Sciences 68: 4065-4078. (cover article)

(35) Yang DC, Tsai CC, Liao YF, Fu HC, Tsay HJ, Huang TF, Chen YH*, Hung SC* (2011) twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish. PLoS One 6: e27324.

(36) Yang DC, Yang MH, Tsai CC, Huang TF, Chen YH*, Hung SC* (2011) Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One 6: e23965.

(37) Lai YY, Pai CW, Tsai IT, Chou CY, Tsai CT*, Chen YH* (2011) Molecular structure and developmental expression of zebrafish atp2a genes. Genes & Genomics 33: 541-548.

(38) Chang MY, Lu JK, Tian YC, Chen YC, Hung CC, Huang YH, Chen YH, Wu MS, Yang CW, Cheng YC* (2011) Inhibition of the P2X7 receptor reduces cystogenesis in PKD. Journal of the American Society of Nephrology 22: 1696-1706.

(39) Liao YF, Chiou MC, Tsai JN, Wen CC, Wang YH, Cheng CC*, Chen YH* (2011) Resveratrol treatment attenuates the wound-induced inflammation in zebrafish larvae through the suppression of myeloperoxidase expression. Journal of Food and Drug Analysis 19: 167-173.

(40) Ho MY, Chiou ML, Du WS, Chang FY, Chen YH, Weng YJ, Cheng CC* (2011) Inductive properties of polypyridyl ruthenium complexes significantly regulate various protein distributions in Escherichia coli. Journal of Inorganic Biochemistry 105: 902-910.

(41) Chen YH, Chang CY, Wang YH, Wen CC, Chen YC, Hu SC, Yu DS, Chen YH* (2011) Embryonic exposure to diclofenac disturbs actin organization and leads to myofibril misalignment. Birth Defects Research Part B-Developmental and Reproductive Toxicology 92: 139-147.

(42) Wen CC*, Huang SYH, Chen YH (2011) Cox regression for current status data with mismeasured covariates. Canadian Journal of Statistics-Revue Canadienne de Statistique 39: 73-88.

(43) Chen YH*, Lin JS (2011) A novel zebrafish mutant with wavy-notochord: an effective biological index for monitoring the copper pollution of water from natural resources. Environmental Toxicology 26: 103-109.

(44) Chen YH, Wen CC, Lin CY, Chou CY, Yang ZS, Wang YH* (2011) UV-Induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of broccoli and cauliflower extracts. Toxicology Mechanisms and Methods 21: 63-69.

(45) Chou CY*, Hsu CH, Wang YH, Chang MY, Chen LC, Cheng SC, Chen YH* (2011) Biochemical and structural properties of zebrafish Capsulin produced by Escherichia coli. Protein Expression and Purification 75: 21-27.

 

2006-2010

(46) Chen YH*, Chiou CH, Chen WL, Jhou YR, Lee YT, Cheng CC* (2010) Rhodamine-ethylenediol, a novel vital fluorescent probe for labeling alkaline phosphatase-rich organelles. Journal of the Chinese Chemical Society 57: 1257-1261.

(47) Liao YF, Chen YH* (2010) Zebrafish is emerging to be a model to find sun-protective compounds. Household & Personal Care Today 4: 6-8. (invited review)

(48) Pai CW, Chen YH* (2010) Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates the UVB-induced apoptosis. Transgenic Research 19: 655-665.

(49) Peng HC, Wang YH, Wen CC, Wang WH, Cheng CC, Chen YH* (2010) Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology 151: 480-486.

(50) Ho MY, Chiou ML, Chang RC, Chen YH, Cheng CC* (2010) Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli. Journal of Inorganic Biochemistry 104: 614-617.

(51) Ho MY, Shieh YT, Liao CL, Chen YH, Cheng CC* (2009) Functional dihydro-1H-imidazole derivatives for MALDI signal enhancement of a lysine-specific chemical modification. Journal of the Chinese Chemical Society 56: 987-994.

(52) Chen YH*, Wang YH, Yu TH, Wu HJ, Pai CW (2009) Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds. Transgenic Research 18: 855-864.

(53) Chen YH*, Lin YT, Lee GH (2009) Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. Bone 44: 777-784. (cover article)

(54) Wang YH, Cheng CC, Lee WJ, Chiou ML, Pai CW, Wen CC, Chen WL, Chen YH* (2009) A novel phenotype-based approach for systematically screening antiproliferation metallodrugs. Chemico-Biological Interactions 182: 84-91.

(55) Wang YH, Wen CC, Yang ZS, Cheng CC, Tsai JN, Ku CC, Wu HJ, Chen YH* (2009) Development of a whole-organism model to screen new compounds for sun protection. Marine Biotechnology 11: 419-429.

(56) Wu SH#, Chen YH#, Huang FL, Chang CH, Chang YF, Tsay HJ* (2008) Multiple regulatory elements mediating neuronal-specific expression of zebrafish sodium channel gene, scn8aa. Developmental Dynamics 237: 2554-2565.

(57) Wang YH, Li CK, Lee GH, Tsay HJ, Tsai HJ*, Chen YH* (2008) Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor axon growth disorganization. Developmental Dynamics 237: 1043-1050.

(58) Chen YH, Huang FL, Cheng YC, Wu CJ, Yang CN, Tsay HJ* (2008) Knockdown of zebrafish Nav1.6 sodium channel impairs embryonic locomotor activities. Journal of Biomedical Science 15: 69-78.

(59) Chen YH*, Tsai HJ* (2008) Myogenic regulatory factors Myf5 and Mrf4 of fish: current status and perspective. Journal of Fish Biology 73: 1872-1890. (invited review)

(60) Chen YH*, Huang YH, Wen CC, Wang YH, Chen WL, Chen LC, Tsay HJ* (2008) Movement disorder and neuromuscular change in zebrafish embryos after exposure to caffeine. Neurotoxicology and Teratology 30: 440-447.

(61) Tsay HJ, Wang YH, Chen WL, Huang MY, Chen YH* (2007) Treatment with sodium benzoate leads to malformation of zebrafish larvae. Neurotoxicology and Teratology 29: 562-569.

(62) Chen YH*, Chen WL, Wang YH, Huang MY, Chern MK (2007) Spatiotemporal expression of zebrafish D-amino acid oxidase during early embryogenesis. Fish Physiology and Biochemistry 33: 73-80.

(63) Chen YH, Wang YH, Chang MY, Lin CY, Weng CW, Westerfield M, Tsai HJ* (2007) Multiple upstream modules regulate zebrafish myf5 expression. BMC Developmental Biology 7: 1.

(64) Lin CY, Yung RF, Lee HC, Chen WT, Chen YH, Tsai HJ* (2006) Myogenic regulatory factor Myf5 and MyoD function distinctly during craniofacial myogenesis of zebrafish. Developmental Biology 299: 594-608.

(65) Lee HC, Huang HY, Lin CY, Chen YH, Tsai HJ* (2006) Foxd3 mediates zebrafish myf5 expression during early somitogenesis. Developmental Biology 290: 359-372.

(66) Wang SL*, Kao TY, Wang CL, Yen YH, Chern MK, Chen YH (2006) A solvent stable metalloprotease produced by Bacillus sp. TKU004 and its application in the deproteinization of squid pen for beta-chitin preparation. Enzyme and Microbial Technology 39: 724-731.

(67) Wang YH#, Chen YH#, Lu CH, Lin YJ, Chang MY, Tsai HJ* (2006) Epidermis-restricted expression of zebrafish cytokeratin II is controlled by a -141/+85 minimal promoter, and cassette -141/-111 is essential for driving the tissue specificity. Differentiation 74: 186-194.

(68) Wang YH#, Chen YH#, Lin YJ, Wu TN, Tsai HJ* (2006) A keratin 18 transgenic zebrafish Tg(k18(2.9):RFP) treated with inorganic arsenite reveals visible overproliferation of epithelial cells. Toxicology Letters 163: 191-197.

(69) Wang YH#, Chen YH#, Lin YJ, Tsai HJ* (2006) Spatiotemporal expression of zebrafish keratin 18 during early embryogenesis and the establishment of a keratin 18:RFP transgenic line. Gene Expression Patterns 6: 335-339.

 

2000-2005

(70) Wang YH, Chen YH, Lu CH, Tsai HJ* (2005) A 23-amino-acid motif spanning the basic domain targets zebrafish myogenic regulatory factor Myf5 into nucleolus. DNA and Cell Biology 24: 651-660.

(71) Lin CY, Chen YH, Lee HC, Tsai HJ* (2004) Novel cis-element in intron 1 represses somite expression of zebrafish myf5. Gene 334: 63-72.

(72) Chen YH, Lee HC, Liu CF, Lin CY, Tsai HJ* (2003) Novel regulatory sequence -82/-62 functions as a key element to drive the somite-specificity of zebrafish myf-5. Developmental Dynamics 228: 41-50.

(73) Wang TM, Chen YH, Liu CF, Tsai HJ* (2002) Functional analysis of the proximal promoter regions of fish rhodopsin and myf-5 genes using transgenesis. Marine Biotechnology 4: 247-255.

(74) Chen YH, Tsai HJ* (2002) Treatment with myf5-morpholino results in somite patterning and brain formation defects in zebrafish. Differentiation 70: 447-456.

(75) Chen YH, Liang CT, Tsai HJ* (2002) Expression, purification and DNA-binding activity of tilapia muscle-specific transcription factor, MyoD, produced in Escherichia coli. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 131: 795-805; Erratum 133: 277-279, (2002).

(76) Chen YH, Lee WC, Liu CF, Tsai HJ* (2001) Molecular structure, dynamic expression and promoter analysis of zebrafish (Danio rerio) myf-5 gene. Genesis 29: 22-35.

(77) Chen YH, Lee WC, Cheng CH, Tsai HJ* (2000) Muscle regulatory factor gene: zebrafish (Danio rerio) myogenin cDNA. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology 127: 97-103.

 

榮譽榜

 

(1) Li WJ (李宛潔), Wang YH, Cheng CC, Chen YH* Leading-drug discovery: using zebrafish embryos as a whole organism platform to screen the ruthenium-derived compounds. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology (15屆中華民國分子細胞生物新知研討會優秀壁報論文獎), Feb. 01-03, Kenting, Taiwan. (2007)

(2) Lee GH (李耕琿), Lin YC (林永蒼), Chen YH* Nuclear factor Y-beta subunit (NF-YB) is required for cartilages organization in zebrafish embryos. The Twenty-two Joint Annual Conference of Biomedical Science (22屆生物醫學聯合學術年會優秀壁報論文獎), Mar. 17-18, Taipei, Taiwan. (2007)

(3) Chang MY (張民彥), Chen YH* Capsulin, a novel cranial neural crest cell marker, is required for craniofacial organization of zebrafish. The Twenty-two Joint Annual Conference of Biomedical Science (22屆生物醫學聯合學術年會優秀壁報論文獎), Mar. 17-18, Taipei, Taiwan. (2007)

(4) Chang MY (張民彥), Lee GH (李耕琿), Chen YH* Capsulin is required for zebrafish cranial myogenesis. 2008 International Symposium on Cell Signaling and Gene Regulation, Nov. 15-16, Tainan, Taiwan. (2008) (Outstanding poster award)

(5) Wu HJ (吳欣儒), Yu TH (游宗翰), Chen YH* Overexpression of Sonic hedgehog leads to cell cycle progression and consequently causes epidermis dysplasia. The Fisheries Society of Taiwan, Dec. 20, Taipei, Taiwan. (2008)(台灣水產學會97年度會員大會暨學術論文發表會優秀壁報論文獎)

(6) Yang ZS (楊智翔), Wen CC, Ku CC, Wu HJ (吳欣儒), Chen YH* Development of a whole-organism model to screen new compounds for sun protection. The Fisheries Society of Taiwan, Dec. 20, Taipei, Taiwan. (2008) (台灣水產學會97年度會員大會暨學術論文發表會優秀壁報論文獎)

(7) Ding YJ (丁玉如), Chen YH* Screening of the chemopreventive compounds against kidney injury from natural products. Taiwan Testing and Quality Assurance Association, Nov. 07, Taipei, Taiwan. (2012)(TTOAA檢驗及品保協會優秀壁報論文獎)

(8) Lin ZY (林子淯), Chen YH* N-methyl-D-aspartate receptor plays a role during zebrafish myogenesis. The Twenty-eight Joint Annual Conference of Biomedical Science (28屆生物醫學聯合學術年會優秀壁報論文獎), Mar. 23-24, Taipei, Taiwan. (2013)

 

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