淡江大學 | 中文 | English

 

蔡旻燁(Min-Yeh Tsai)

物理化學、化學生物、計算生物物理

 

 


經歷

淡江大學化學系約聘助理教授(2018/8~)

美國萊斯大學化學系博士後研究員(2014~2018)

國立交通大學應用化學系博士後研究員--研發替代役(2011~2014)

學歷

國立臺灣大學化學研究所--博士(2006~2011)

國立臺灣師範大學化學系--學士(2001~2005)

Professional Experience

Assistant Professor, Tamkang University, New Taipei City, Taiwan (2018/8~)

Postdoctoral Research Associate, Rice University, Houston, TX (2014~2018)

R&D Fellow, Alternative Military Duty, National Chiao Tung University, Hsinchu, Taiwan (2011~2014)

Education

Ph.D. in Physical Chemistry, National Taiwan University, Taipei, Taiwan (2006~2011)

B.Sc. in Chemistry, National Taiwan Normal University, Taipei, Taiwan (2001~2005)


蔡旻燁

Office: C413

Lab: C412

Contact:

    Tel: (+886)-2-2621-5656 ext 2843

    Email: mytsai@tku.edu.tw; mytsai886@gmail.com

    Personal website: Link

Research Interests:

  1. Disease-related protein-protein & protein-DNA interactions
  2. Carbohydrate-mediated protein aggregation
  3. Systems biology of neurodegenerative diseases

 

Honors & Awards

  • Postdoctoral Research Abroad Program, Ministry of Science Technology (MOST), Taiwan 2013.11
  • National Taiwan University Dean of science award for PhD 2010-2011
  • Chinese Chemical Society Dissertation Award of Excellence in Physical Chemistry 2011    

 

 

Research Articles:

(1) Lin, X.; Roy, S.; Jolly, M. K.; Bocci, F.; Schafer, N. P.; Tsai, M.-Y.; Chen, Y.; He, Y.; Grishaev, A.; Weninger, K.; et al. PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer. J. Mol. Biol. 2018, 430, 2422–2438. 


(2) Zheng, W.; Tsai, M.-Y.; Wolynes, P. G. Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40). J. Am. Chem. Soc. 2017, 139, 16666–16676.

 

(3) Tsai, M.-Y.; Zhang, B.; Zheng, W.; Wolynes, P. G. Molecular Mechanism of Facilitated Dissociation of Fis Protein from DNA. J. Am. Chem. Soc. 2016, 138, 13497−13500.

 

(4) Zheng, W.; Tsai, M.-Y.; Chen, M.; Wolynes, P. G. Exploring the Aggregation Free Energy Landscape of the Amyloid-β Protein (1-40). Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 11835–11840.

 

(5) Chen, M.; Tsai, M.-Y.; Zheng, W.; Wolynes, P. G. The Aggregation Free Energy Landscapes of Polyglutamine Repeats. J. Am. Chem. Soc. 2016, 138, 15197–15203.

 

(6) Parra, R. G.; Schafer, N. P.; Radusky, L. G.; Tsai, M.-Y.; Guzovsky, A. B.; Wolynes, P. G.; Ferreiro, D. U. Protein Frustratometer 2: A Tool to Localize Energetic Frustration in Protein Molecules, Now with Electrostatics. Nucleic Acids Res. 2016, 44, W356–W360.

 

(7) Shiu, Y.-J.; Hayashi, M.; Shih, O.; Su, C.; Tsai, M.-Y.; Yeh, Y.-Q.; Su, C.-J.; Huang, Y.-S.; Lin, S.-H.; Jeng, U.-S. Intrinsic Coordination for Revealing Local Structural Changes in Protein Folding-Unfolding. Phys. Chem. Chem. Phys. 2016, 18, 3179–3187.

 

(8) Tsai, M.-Y.; Zheng, W.; Balamurugan, D.; Schafer, N. P.; Kim, B. L.; Cheung, M. S.; Wolynes, P. G. Electrostatics, Structure Prediction, and the Energy Landscapes for Protein Folding and Binding. Protein Sci. 2016, 25, 255–269.

 

(9) Tsai, M.-Y.*; Yuan, J.-M.; Lin, S.-H. Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model. J. Chin. Chem. Soc. 2015, 62, 21–25.

 

(10) Tsai, M.-Y.*; Yuan, J.-M.; Yamaki, M.; Lin, C.-K.; Lin, S. H. Molecular Dynamics Insight into the Diverse Thermodynamic Behavior of a Beta-Hairpin Peptide. J. Chin. Chem. Soc. 2013, 60, 915–928.

 

(11) Lin, C.-K.; Shih, C.-C.; Niu, Y.; Tsai, M.-Y.; Shiu, Y.-J.; Zhu, C.; Hayashi, M.; Lin, S. H. Theoretical Study on Structure and Sum-Frequency Generation (SFG) Spectroscopy of Styrene–Graphene Adsorption System. J. Phys. Chem. C 2013, 117, 1754–1760.

 

(12) Tsai, M.-Y.*; Yuan, J.-M.; Teranishi, Y.; Lin, S. H. Thermodynamics of Protein Folding Using a Modified Wako-Saitô-Muñoz-Eaton Model. J. Biol. Phys. 2012, 38, 543–571.

 

(13) Tsai, M. Y.*; Morozov, A. N.; Chu, K. Y.; Lin, S. H. Molecular Dynamics Insight into the Role of Tertiary (foldon) Interactions on Unfolding in Cytochrome c. Chem. Phys. Lett. 2009, 475, 111–115.

 

(14) Morozov, A. N.; Shiu, Y. J.; Liang, C. T.; Tsai, M. Y.; Lin, S. H. Nonadditive Interactions in Protein Folding: The Zipper Model of Cytochrome C. J. Biol. Phys. 2007, 33, 255–270.

Book Chapters

(1) Tsai, M.-Y.*; Yuan, J.-M.; Lin, S. H. Chapter 6: Thermodynamics and Kinetics of Protein Folding and Aggregation. In Biophysics and Biochemistry of Protein Aggregation: Experimental and Theoretical Studies on Folding, Misfolding, and Self-Assembly of Amyloidogenic Peptides; Yuan, J.-M.; Zhou, H.-X., Eds.; World Scientific, 2017.