淡江大學 | 中文 | English

 

蔡旻燁（Min-Yeh Tsai）

物理化學、化學生物、計算生物物理

 

 

經歷

淡江大學化學系專任助理教授（2018/8~）

美國萊斯大學化學系博士後研究員（2014~2018）

國立交通大學應用化學系博士後研究員--研發替代役（2011~2014）

學歷

國立臺灣大學化學研究所--博士（2006~2011）

國立臺灣師範大學化學系--學士（2001~2005）

Professional Experience

Assistant Professor, Tamkang University, New Taipei City, Taiwan (2018/8~)

Postdoctoral Research Associate, Rice University, Houston, TX (2014~2018)

R&D Fellow, Alternative Military Duty, National Chiao Tung University, Hsinchu, Taiwan (2011~2014)

Education

Ph.D. in Physical Chemistry, National Taiwan University, Taipei, Taiwan (2006~2011)

B.Sc. in Chemistry, National Taiwan Normal University, Taipei, Taiwan (2001~2005)
蔡旻燁

Office: C413

Lab: C412

Contact:

    Tel: (+886)-2-2621-5656 ext 2843

    Email: mytsai@mail.tku.edu.tw; mytsai886@gmail.com

    Lab website: mytsai.cc

Research Interests:

  1. Disease-related protein-protein & protein-DNA interactions
  2. Oligomer mediated drugging through computationally identified hotspots
  3. Systems biology of neurodegenerative diseases

 

Honors & Awards/Grants

  • Research Project, Ministry of Science Technology (MOST), Taiwan 2021.8 (2-year grant)
  • TKU Teaching Award in academic year 2019 (108學年度優良教師)
  • Research Project, Ministry of Science Technology (MOST), Taiwan 2019.4 (2-year grant)
  • Postdoctoral Research Abroad Program, Ministry of Science Technology (MOST), Taiwan 2013.11 (1-year grant)

  • National Taiwan University Dean of science award for PhD 2010-2011

  • Chinese Chemical Society Dissertation Award of Excellence in Physical Chemistry 2011    

 

Selected Puplications 

*Corresponding author

†Contributed equally to this work

 

  1. Chen, X.; Tsai, M.-Y.*; Wolynes, P. G.* The Role of Charge Density Coupled DNA Bending in Transcription Factor Sequence Binding Specificity: A Generic Mechanism for Indirect Readout. J. Am. Chem. Soc. 2022, 144 (4), 1835–1845.
  2. Ma, Y.-W.; Lin, T.-Y.; Tsai, M.-Y.* Fibril Surface-dependent Amyloid Precursors revealed by Coarse-grained Molecular Dynamics Simulation. Front. Mol. Biosci. 2021, 8, 719320.
  3. Tsai, M.-Y.*,†;Shen, J.-L.†; Schafer, N. P.; Wolynes, P. G.*, Modeling Protein Aggregation Kinetics: The Method of Second Stochasticization. J. Phys. Chem. B. 2021, 125 (4), 1118–1133.
  4. Tsai, M.-Y.; Zheng, W; Chen, M.; Wolynes, P. G.* Multiple Binding Configurations of Fis Protein Pairs on DNA: Facilitated Dissociation versus Cooperative Dissociation. J. Am. Chem. Soc. 2019, 141 (45), 18113−18126.
  5. Tsai, M.-Y.; Zhang, B.; Zheng, W.; Wolynes, P. G.* Molecular Mechanism of Facilitated Dissociation of Fis Protein from DNA. J. Am. Chem. Soc. 2016, 138 (41), 13497−13500.
  6. Zheng, W.; Tsai, M.-Y.; Wolynes, P. G.* Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40). J. Am. Chem. Soc. 2017, 139 (46), 16666–16676.
  7. Zheng, W.; Tsai, M.-Y.; Chen, M.; Wolynes, P. G.* Exploring the Aggregation Free Energy Landscape of the Amyloid-β Protein (1-40). Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (42), 11835–11840.
  8. Tsai, M.-Y.; Zheng, W.; Balamurugan, D.; Schafer, N. P.; Kim, B. L.; Cheung, M. S.; Wolynes, P. G.* Electrostatics, Structure Prediction, and the Energy Landscapes for Protein Folding and Binding. Protein Sci. 2016, 25 (1), 255–269.
  9. Tsai, M.-Y.*; Yuan, J.-M.; Teranishi, Y.; Lin, S. H. Thermodynamics of Protein Folding Using a Modified Wako-Saitô-Muñoz-Eaton Model. J. Biol. Phys. 2012, 38 (4), 543–571.

Full publications:

2018.8-Current

 

  1. Chen, X.; Tsai, M.-Y.*; Wolynes, P. G.* The Role of Charge Density Coupled DNA Bending in Transcription Factor Sequence Binding Specificity: A Generic Mechanism for Indirect Readout. J. Am. Chem. Soc. 2022, 144 (4), 1835–1845.
  2. Chen, X.; Lu, W.; Tsai, M.-Y.; Jin, S.; Wolynes, P. G. Exploring the Folding Energy Landscapes of Heme Proteins Using a Hybrid AWSEM-Heme Model. J. Biol. Phys. 2022. https://doi.org/10.1007/s10867-021-09596-3.
  3. Ma, Y.-W.; Lin, T.-Y.; Tsai, M.-Y.* Fibril Surface-dependent Amyloid Precursors revealed by Coarse-grained Molecular Dynamics Simulation. Front. Mol. Biosci. 2021, 8, 719320.
  4. Tsai, M.-Y.*,†;Shen, J.-L.†; Schafer, N. P.; Wolynes, P. G.*, Modeling Protein Aggregation Kinetics: The Method of Second Stochasticization. J. Phys. Chem. B 2021, 125 (4), 1118–1133.
  5. Jin, S.; Contessoto, V. S.; Chen, M.; Schafer, N. P.; Lu, W.; Chen, X.; Bueno, C.; Hajitaheri, A.; Sirovetz, B. J.; Davtyan, A.; Papoian, G. A.; Tsai, M.-Y.; Wolynes, P. G.* AWSEM-Suite: A Protein Structure Prediction Server Based On Template-guided, Coevolutionary-enhanced Optimized Folding Landscapes. Nucleic Acids Res. 2020, 48 (W1), W25-W30.
  6. Tsai, M.-Y.; Zheng, W; Chen, M.; Wolynes, P. G.* Multiple Binding Configurations of Fis Protein Pairs on DNA: Facilitated Dissociation versus Cooperative Dissociation. J. Am. Chem. Soc. 2019, 141 (45), 18113−18126.
  7. Tsai, M.-Y.* Role of Physical Nucleation Theory in Understanding Conformational Conversion between Pathogenic and Non-pathogenic Aggregates of Low-Complexity Amyloid Peptides. Res. Chem. Intermed. 2019, 45, 5357-5373.

 Before TKU

 

  1. Lin, X.; Kulkarni, P.; Bocci, F.; Schafer, N. P.; Roy, S.; Tsai, M.-Y.; He, Y.; Chen, Y.; Rajagopalan, K.; Mooney, S. M.; et al. Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level. Biomolecules 2019, 9 (2), 77. 
  2. Lin, X.; Roy, S.; Jolly, M. K.; Bocci, F.; Schafer, N. P.; Tsai, M.-Y.; Chen, Y.; He, Y.; Grishaev, A.; Weninger, K.; et al. PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer. J. Mol. Biol. 2018, 430 (16), 2422–2438.
  3. Zheng, W.; Tsai, M.-Y.; Wolynes, P. G.* Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40). J. Am. Chem. Soc. 2017, 139 (46), 16666–16676.
  4. Tsai, M.-Y.*; Yuan, J.-M.; Lin, S. H. Chapter 6: Thermodynamics and Kinetics of Protein Folding and Aggregation. In Biophysics and Biochemistry of Protein Aggregation: Experimental and Theoretical Studies on Folding, Misfolding, and Self-Assembly of Amyloidogenic Peptides; Yuan, J.-M., Zhou, H.-X., Eds.; World Scientific, 2017.
  5. Chen, M.; Tsai, M.-Y.; Zheng, W.; Wolynes, P. G.* The Aggregation Free Energy Landscapes of Polyglutamine Repeats. J. Am. Chem. Soc. 2016, 138 (46), 15197–15203.
  6. Zheng, W.; Tsai, M.-Y.; Chen, M.; Wolynes, P. G.* Exploring the Aggregation Free Energy Landscape of the Amyloid-β Protein (1-40). Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (42), 11835–11840.
    → Featured in Rice University News & Media, Oct 3, 2016 
  7. Tsai, M.-Y.; Zhang, B.; Zheng, W.; Wolynes, P. G.* Molecular Mechanism of Facilitated Dissociation of Fis Protein from DNA. J. Am. Chem. Soc. 2016, 138 (41), 13497−13500.
  8. Parra, R. G.; Schafer, N. P.; Radusky, L. G.; Tsai, M.-Y.; Guzovsky, A. B.; Wolynes, P. G.; Ferreiro, D. U.* Protein Frustratometer 2: A Tool to Localize Energetic Frustration in Protein Molecules, Now with Electrostatics. Nucleic Acids Res. 2016, 44 (W1), W356–W360.
  9. Shiu, Y.-J.; Hayashi, M.*; Shih, O.; Su, C.; Tsai, M.-Y.; Yeh, Y.-Q.; Su, C.-J.; Huang, Y.-S.; Lin, S.-H.; Jeng, U.-S.* Intrinsic Coordination for Revealing Local Structural Changes in Protein Folding-Unfolding. Phys. Chem. Chem. Phys. 2016, 18 (4), 3179–3187.
  10. Tsai, M.-Y.; Zheng, W.; Balamurugan, D.; Schafer, N. P.; Kim, B. L.; Cheung, M. S.; Wolynes, P. G.* Electrostatics, Structure Prediction, and the Energy Landscapes for Protein Folding and Binding. Protein Sci. 2016, 25 (1), 255–269.
  11. Tsai, M.-Y.*; Yuan, J.-M.; Lin, S.-H. Thermodynamic Insight into Protein Aggregation Using a Kinetic Ising Model. J Chin Chem Soc 2015, 62 (1), 21–25.
  12. Tsai, M.-Y.*; Yuan, J.-M.; Yamaki, M.; Lin, C.-K.; Lin, S. H. Molecular Dynamics Insight into the Diverse Thermodynamic Behavior of a Beta-Hairpin Peptide. J Chin Chem Soc 2013, 60 (7), 915–928.
  13. Lin, C.-K.*; Shih, C.-C.; Niu, Y.; Tsai, M.-Y.; Shiu, Y.-J.; Zhu, C.; Hayashi, M.; Lin, S. H. Theoretical Study on Structure and Sum-Frequency Generation (SFG) Spectroscopy of Styrene–Graphene Adsorption System. J. Phys. Chem. C 2013, 117 (4), 1754–1760.
  14. Tsai, M.-Y.*; Yuan, J.-M.; Teranishi, Y.; Lin, S. H. Thermodynamics of Protein Folding Using a Modified Wako-Saitô-Muñoz-Eaton Model. J. Biol. Phys. 2012, 38 (4), 543–571.
  15. Tsai, M. Y.*; Morozov, A. N.; Chu, K. Y.; Lin, S. H. Molecular Dynamics Insight into the Role of Tertiary (foldon) Interactions on Unfolding in Cytochrome c. Chem. Phys. Lett. 2009, 475 (1), 111–115.
  16. Morozov, A. N.*; Shiu, Y. J.; Liang, C. T.; Tsai, M. Y.; Lin, S. H. Nonadditive Interactions in Protein Folding: The Zipper Model of Cytochrome C.