淡江大學 | 中文 | English

 

施增廉(Tzenge-Lien Shih)

天然物合成

藥物設計與合成 


淡江大學理學院院長(2019-迄今)

淡江大學化學系系主任(2015-2019)

淡江大學化學系教授(2013-迄今)
淡江大學化學系副教授(2006-2013
淡江大學化學系助理教授(2001-2006
長庚大學助理教授(2000-2001
中央研究院生化所博士後研究員(1998-2000
美國俄亥俄州立大學化學系博士後研究員(1997-1998
美國普渡大學化學博士(1992-1997
美國田納西大學化學碩士(1989-1992
淡江大學化學系助教(1988-1989
淡江大學化學系學士(1982-1986

Tamkang University, Dean of College of Science

Tamkang University, Chairman

Tamkang University, Professor
Tamkang University, Associate Professor
Tamkang University, Assistant Professor
Chang Gung University, Assistant Professor
Academia Sinica, Postdoctoral Research Fellow
The Ohio State University, Postdoctoral Research Fellow
Purdue University, Ph.D.
The University of Tennessee, Knoxville , M.S.
Tamkang University, Teaching Assistant
Tamkang University, B.S.


施增廉



Email address
tlshih@mail.tku.edu.tw

研究方向

1. 抗癌、抗氧化、抗發炎、抗凝血藥物的合成

2. 天然物合成 

 

Research Interests

1. Synthesis of anti-cancer, antioxidant, anti-inflammatory, and anticoagulant agents

2. Natural products synthesis

專書 (Book)

有機化學精華 (Essential Organic Chemistry; 3rd ed; Paula Yurkanis Bruice). 2019.07
施增廉 編譯

 

專利(Patent)

1.殺菌劑及其用途 台灣發明專利 胡安仁 施增廉 洪崧壬 陳灝平 發明第 I748646

2.己二烯-3,4二酮類或喹㗁啉類化合物或其醫藥學上可接受之鹽用於製備抑制胰臟癌之藥物的用途  

 台灣發明專利 施增廉、陳日榮、王睿瑜、卓書澤、張峻豪

 

 

 

期刊論文

1.Cheng, Y.-J.; Li, C.-W.; Kuo, C.-L.; Shih,* T.-L.; Chen,* J.-J. “Improved Synthesis of Asymmetric Curcuminoids and Their Assessment as Antioxidants” Molecules 2022, 27, 2547.

2. Wang, R.-Y.; Li, C.-W.; Cho, S.-T.; Chang, C-H.; Chen,* J.-J.; Shih,* T.-L. “Synthesis of cinnamils and quinoxalines and their biological evaluation as anti-cancer agents” Arch. Pharm. 2022, 355, 2100448

3. Shih, T.-L.; Lin, K.-H.; Chen, R.-J.; Chen, T.-Y.; Kao, W.-T.; Liu, J.-W.; Wang, H.-H.; Peng, H.-Y.; Sun, Y.-Y.; Lu, W.-J.* “A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI” J. Cell. Mol. Med. 2021, 259434-9446.

4. Tsai, H. Y.; Huang, Y.-T.; Kuo, C.-L.; Kuo, C.-J.; Hu,* A.; Chen,* J.-J.; Shih,* T.-L. “A case study of the iodine-mediated cyclization of C2’-OH- and C2-OH-chalcones toward the synthesis of flavones. Reinvestigation of the mechanisms” J. Chin. Chem. Soc. 2021, 68, 1334-1338.

5. Hung, S.-J.; Hong, Y.-A.; Lin, K.-Y.; Hua, Y.-W.; Kuo, C.-J.; Hu, A.; * Shih, T.-L.;* Chen, H.-P.* “Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids” Int. J. Mol. Sci. 2020, 21, 9024.

6. Tung, C.-H.; Lu, Y.-T.; Kao, W.-T.; Liu, J.-W.; Lai, Y.-H.; Jiang, S.-J.; Chen*, H.-P.; Shih*, T.-L. “Discovery of a more potent anti-cancer agent than C4-benzazole 1,8-naphthalimide derivatives against murine melanoma” J. Chin. Chem. Soc. 2020, 67, 1254-1262. (Cover figure).

7. Wang, R.-Y.; Kao, W.-T.; Shih*, T.-L. “Synthesis of selenium-containing biindolyls and their Diels-Alder reaction toward the synthesis of hetero-annulated[a]- and [c]-carbazoles” J. Chin. Chem. Soc. 2020, 67, 829-837.

8. Tsai, M.-C.; Huang, P. Y.; Syu, L. S.; Shih*, T.-L. “Synthesis of novel isoquinolino[5,4-ab]phenanthridine derivatives via Pictet-Spengler reaction” Synthesis 2019, 51, 1377-1382.

9. Yang, M.-Y.; Khine, A. A.; Liu, J.-W.; Cheng, H.-C.; Hu*, A.; Chen*, H.-P.; Shih*, T.-L. "Resolution of Isoborneol and its Isomers by GC/MS to Identify “Synthetic” and “Semi-synthetic” Borneol Products." Chirality 2018, 30, 1233-1239.

10. Shih, T.-L.; Liu, M.-H.; Li, C.-W.; Kuo*, C.-F. “Halo-Substituted Chalcones and Azachalcones-Inhibited, Lipopolysaccharited-Stimulated, Pro-Inflammatory Responses through the TLR4-Mediated Pathway” Molecules 2018, 23, 597.

11. Ho, T.-J.; Hung, C.-C.; Shih, T.-L.; Yiin, L.-M.; Chen, H.-P “Investigation of borneols sold in Taiwan by chiral gas chromatography” J. Food. Drug. Anal. 2018, 26, 348-352.

12. Li, C.-W.; Shen, T.-H; Shih*, T.-L. “Reinvestigation of synthesis of halo-substituted 3-phenyl-1-(2-pyridyl)-2-propen-1-ones (azachalcones). A tandem reaction for formation of penta-substituted cyclohexanols” Tetrahedron 2017, 73, 4644-4652.

13. Lu, Y.-T.; Chen, T.-L.; Chang, K.-S.; Chang, C.-M.; Wei, T.-Y.; Liu, J.-W.; Hsiao, C.-A.; Shih*, T.-L. “Synthesis of novel C4-benzazole naphthalimide derivatives with potentanti-tumor properties against murine melanoma” Bioorg. Med. Chem. 2017, 25, 789-794.

14. Chen, Y.-R.; Cho, Y. C.; Shih*, T.-L. “Reinvestigation of ortho-amidoacetophenones’ cyclization mediated by trimethylsilyl trifluoromethanesulfonate. The Lewis-acid-assisted and Brønsted-acid-catalyzed reaction” Tetrahedron 2016, 72, 2006-2011.

15. Shih*, T.-L.; Liao, W.-Y.; Yen, W.-C. “Regioselective fluorination in synthesis of deoxyfluoro quercitols from D-(-)-quinic acid” Tetrahedron 2014, 70, 9621-9627.

16. Shih*, T.-L.; Chou, C.-E.; Liao, W.-Y.; Hsiao, C.-A. “Copper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids” Tetrahedron 2014, 70, 3657-3664.

17. Tai, C.-K.; Yeh, P.-L.; Wu, Y.-S.; Shih*, T.-L.; Wang*, B.-C. “Theoretical investigation of conformational stabilities and 13C NMR chemical shifts of a seven-membered ring thiosugar, (3R,4R,5R,7S)-7-(hydroxymethyl)thiepane-3,4,5-triol” J. Mol. Stru. 2014, 1068, 84-93.

18. Shih*, T.-L.; Gao, W.-L. “The First Synthesis of 7-(Hydroxymethyl)thiepane-3,4,5-triols from D-(-)-Quinic Acid” Tetrahedron 2013, 69, 1897-1903.

19. Chen, H.-H.; Lin, H.-A.; Lai, Y.-H.; Lin, S.-Y.; Chiang, C.-H.; Hsu*, H.-F.; Shih*, T.-L.; Lee, J.-J.; Lai, C.-C.; Kuo, T.-S.; “Enantiotropic Nematics From Cross-Like 1,2,4,5-Tetrakis(4-Alkyl-4-Ethynylbiphenyl)Benzenes And Their Biaxiality Studies” Chem. Eur. J. 2012, 18, 9543-9551.

20. Shih*, T.-L.; Hsiao, C.-A.; Lin, Z.-Y.; Chen*, Y.-H. “An Alternative Synthesis of 3’,4’-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae” Molecules 2012, 17, 8206-8216.

21. Chen, H.-H.; Lin, H.-A.; Chien, S.-C.; Wang, T.-H.; Hsu*, H.-F.; Shih*, T.-L.; Wu, C. “Single-component room-temperature discotic nematic liquid crystals formed by introducing an attraction-enhancing inplane protrusion onto the hexa(phenylethynyl)benzene core” J. Mater. Chem. 2012, 22, 12718-12722.

22. Yeh, P.-L.; Tai, C.-K.; Shih*, T.-L.; Hsiao, H.-L.; Wang*, B.-C. “Conformational analysis of a seven-membered ring azasugar, (3R,4R,6S)-trihydroxyazepane: Comparison of GIAO calculation andexperimental NMR spectra on 13C chemical shifts“ J. Mol. Stru. 2012, 1018, 64-71.

23. Shih*, T.-L.; Yang, S.-Y. “Regioselectivity in the Ring Opening of Epoxide for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid” Molecules 2012, 17, 4498-4507.

24. Chen*, Y.-H.; Yang, Z.-S.; Wen, C.-C.; Chang, Y.-S.; Wang*, B.-C.; Hsiao, C.-A.; Shih*, T.-L. “Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae” Food Chemistry. 2012, 134, 717-724.

25. Shih*, T.-L.; Liang, M.-C.; Wu, K.-D.; Lin*, C.-H “Synthesis of Polyhydroxy 7- and N-Alkyl-Azepanes as potent Glycosidase Inhibitors” Carbohydr. Res. 2011, 346, 183-190.

26. Shih*, T.-L.; Li, H.-Y.; Ke, M.-S.; Kuo, W.-S. “Synthesis of a New Family of Aminocyclitols from D-(-)- Quinic Acid” Synth. Commun. 2008, 38, 4139-4149.

27. Shih*, T.-L.; Yang, R.-Y.; Li, S.-T.; Chiang, C.-F.; Lin*, C.-H. ''Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from D-(-)-Quinic Acid as Potent Glycosidase Inhibitors " J. Org. Chem. 2007, 72, 4258-4261.

28. Shih*, T.-L.; Fang, Y.-J. ''An expeditious synthesis of new 3,4,6-trihydroxythiepanes from D-(-)-quinic acid'' Synth. Commun. 2007, 37, 3337-3349.

29. Shih*, T.-L.; Lin, Y.-L. ''Epoxidation of protected 1,4,5-cyclohex-2-ene-triols and their acid hydrolysis to synthesize quercitols from D-(-)-quinic acid" Synth. Commun. 2005, 35, 1809-1817.

30. Shih*, T.-L.; Lin, Y. -L.; Kuo, W. -S. "Highly stereoselective and stereospecific syntheses of a variety of quercitols from D-(-)-quinic acid" Tetrahedron 2005, 61, 1919-1924.

31. Shih*, T.-L.; Kuo, W.-S.; Lin, Y.-L. "A facile synthesis of a new trihydorxy piperidine derivative and (+)-proto-quercitol from D-(-)-quinic acid" Tetrahedron Lett. 2004, 45, 5751-5754.

32. Shih*, T.-L.; Tseng, J.-H. "An efficient synthesis of L-allono-1,4-lactone from 2,3;5,6-di-o-isopropylidene-D-mannono-1,4-lactone" Tetrahedron Lett. 2004, 45, 1789-1791.

33. Paquette, L.A.; Zeng, Q.; Wang, H.-L.; Shih, T.-L.“From Carbohydrates to the Discovery of Pronounced Heteroatomic Effects on Anionically Accelerated [3,3]-Sigmatropic Rearrangements” Eur. J. Org. Chem. 2000, 2187.

34. Shih*, T.-L.; Wu*, S.-H.“ Efficient Syntheses of (-)-Shikimate and (-)-Quinate 3-Phosphated via Trans Vicinal Diol Protection with 2,2,3,3-Tetramethoxy ButaneTMBof Shikimic and Quinic Acid ” Tetrahedron Lett. 2000, 41, 2957.

35. Shih*, T.-L.; Chen, M.-C.; Wu*, S.-H. “Chemoenzymatic Preparation of 4-O-Acetyl Sialic Acid Derivative” Tetrahedron Lett. 2000, 41, 7921.

36. Paquette, L. A.; Shih, T.-L.; Zeng, Q.; Hofferberth, J. E. ”Synthesis of Stereodefined Z-Vinyl Iodides from Carbohydrates as a Prelude to C/D Ring Assembly in Taxanes” Tetrahedron Lett. 1999, 40, 3519.

37. Paquette, L. A.; Wang, H.-L.; Zeng, Q.; Shih, T.-L.”Heteroatomic Modulation of Oxyanionic Cope Rearrangement Rates. Consequences on Competing Nucleophilic Cleavage of an Oxetane Ring in Precursors to Paclitaxel” J. Org. Chem. 1998, 63, 6432.

38. Andrus, M. B.; Shih, T.-L “Synthesis of Tuckolide, a New Cholesterol Biosynthesis Inhibitor” J. Org. Chem. 1996, 61, 8780.

39. Li, C.; Shih, T.-L.; Jeong, J. U.; Arasappan, A.; Fuchs, P. L. ”The Use of Tetramethylguanidinium Azide in Non-halogenated Solvents Avoids Potential Explosion Hazards” Tetrahedron Lett. 1994, 35, 264.

40. Wu, C.-L; Huang, C.-D.; Shih, T.-L.“A Sesquiterpene Oxide of a Novel Skeleton From the Liverwort Plagiochila peculiaris” Tetrahedron Lett. 1993, 34, 4855.

41. Johnson, S. C.; Dahl, J.; Shih, T.-L.; Schedler, D. J. A.; Anderson, L.; Benjamin, T. L.; Baker, D. C.“Synthesis and Evaluation of 3-Modified 1D-Myo-Inositols as Inhibitors and Substrates of Phosphatidylinositol Synthase and Inhibitors of Myo-Inositol Uptake by Cells” J. Med. Chem. 1993, 36, 3628.