淡江大學 | 中文 | English

 

莊子超(Tzu-Chao Chuang)

生物化學、細胞分子生物學


淡江大學化學系副教授(2011-迄今)
淡江大學化學系助理教授(2004-2011
國防醫學院生物化學所博士後研究員
國防醫學院生命科學所博士
國防醫學院生物化學所碩士
中山醫學院營養學系學士

Tamkang University, Associate Professor
Tamkang University, Assistant Professor
National Defense Medical Center, Postdoctoral Research Fellow
National Defense Medical Center, Ph. D.
National Defense Medical Center, M.S.
Chung Shan Medical College, B.S.


莊子超

研究專長及興趣

生物化學、癌症生化學、天然物抗癌機制

 

 

 

Email address: tcbc@mail.tku.edu.tw

 

近年代表性著作

近期著作:

1.    M.-C. Kao*, G.-Y. Liu, T.-C. Chuang, Y.-S. Lin, J.-A. Wuu, S.-L. Law, The N-terminal 178-amino-acid domain only of the SV40 large T antigen acts as a transforming suppressor of the HER-2/neu oncogene. Oncogene. 16 (1998) 547-554.

2.    M.-C. Kao*, S.-L. Law, T.-C. Chuang and Y.-S. Lin, In virto gene transfer in mammalian cells via a new cationic liposome formulation. Oncology reports. 5 (1998) 625-629.

3.    S.-L. Law, M.-C. Kao and T.-C. Chuang, Formulation of transfection reagent of sphingosine and dioleoylphosphatidyl-ethanolamine. (2000) (ROC Patent #114360)

4.    T.-C. Chuang, Y. Yu, Y.-S. Lin, S.-S. Wang, M.-C. Kao*, The N-terminal domain of SV40 Large T antigen represses the HER2/neu-mediated transforming and metastatic potential in breast cancers. FEBS Lett. 511 (2002) 46-50.

5.    T.-C. Chuang, T-D. Way, Y.-S. Lin, Y.-C. Lee, S.-L. Law, M.-C. Kao*, The Epstein-Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2/neu oncogene. FEBS Lett. 532 (2002) 135-142.

6.    T.-C. Chuang, Y.-C. Lee, G.-Y. Liu, Y.-S. Lin, J.-Y. Li, V. Wang, S.-L. Law, M.-C. Kao*, EBNA1 may prolong G2/M phase and sensitizes HER2/neu-overexpressing ovarian cells to both topoisomerase II-targeting and paclitaxel drugs. Biochem. Biophys. Res. Commun. 307 (2003) 653-659.

7.    J.-Y. Li, T.-C. Chuang, A.-H. Yang, C.-K. Hsu, M.-C. Kao*, Clinicopathological relevance of HER2/neu and a related gene-protein cubic regression correlation in colorectal adenocarcinomas in Taiwan, Int J Oncol. 26 (2005) 933-944.

8.    V. Wang, T.-C. Chuang, Y.-D. Hsu, W.-Y. Chou, M.-C. Kao*, Nitric oxide induces prion protein via MEK and p38 MAPK signaling, Biochem. Biophys. Res. Commun. 333 (2005) 95-100.

9.    S.-L. Law*, T.-C. Chuang, M.-C. Kao, Y.-S. Lin, K.-J. Huang, Gene transfer mediated by sphingosine/ dioleoylphosphatidylethanolamine liposomes in the presence of poloxamer 188, Drug Deliv. 3 (2006) 61-67.

10.     T.-C. Chuang*, J.-Y. Liu, C.-T. Lin, Y.-T. Tang, M.-H. Yeh, S.-C. Chang, J.-W. Li, M.-C. Kao*, Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy, FEBS Lett. 581 (2007) 4443-4449.

11.     C.-C. Ou, S.-C. Hsu, Y.-H. Hsieh, W.-L. Tsou, T.-C. Chuang, J.-Y. Liu*, M.-C. Kao*, Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. Carcinogenesis 29 (2008) 299-306.

12.     S.-C. Hsu, C.-C. Ou, J.-W. Li, T.-C. Chuang*, H.-P. Kuo, J.-Y, Liu, C.-S. Chen, S.-C. Lin, C.-H. Su, M.-C. Kao*, Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest, J Ethnopharmacol. 120 (2008) 394-401. 

13.     J.-Y. Liu, T.-C. Chuang*, T.-D. Way, T.-C. Tsai, C.-L. Hu, G.-Y. Liu, S.-S.-Wang, J.-G. Chung, M.-C. Kao*, The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene, Cancer Lett. 273 (2009) 273-280.

14.     V. Wang#, T.-C. Chuang#, B.-W. Soong, D.-E. Shan*, M.-C. Kao*, Octarepeat changes of prion protein in Parkinson's disease, Parkinsonism Relat Disord. 15 (2009) 53-58. (#co-first author)

15.     S.-C. Hsu, C.-C. Ou, T.-C. Chuang*, J.-W. Li, Y.-J. Lee, V. Wang, J.-Y. Liu, C.-S. Chen, S.-C. Lin*, M.-C. Kao*, Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: in vitro and in vivo, Cancer Lett. 281 (2009) 108-116.

16.     V. Wang*, S.-Y. Chen, T.-C. Chuang, D.-E Shan, B.-W. Soong, M.-C. Kao*, Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson’s disease. Clin Biochem. 43 (2010) 979-982.

17.     H.-P. Kuo, T.-C. Chuang, M.-H. Yeh, S.-C. Hsu, T.-D. Way, P.-Y. Chen, S.-S. Wang, Y.-H. Chang, M.C. Kao*, J.Y. Liu*, Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulating the HER2/PI3K/Akt signaling pathway, J Agric Food Chem. 59 (2011) 8216-8224.

18.     T.-C. Chuang*, S.-C. Hsu, Y.-T. Cheng, W.-S. Shao, K. Wu, G.-S. Fang, C.-C. Ou, V. Wang, Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells, Cancer Lett. 311 (2011) 11-19.