李長欣(Chang-Shin Lee) |
物理化學、結構生物學、生醫核磁共振
Physical Chemistry, Structure Biology, Biomedicine NMR |
淡江大學化學系助理教授(2003~迄今)
中央研究院生化所博士後研究員(1997-1999)
清華大學化學系博士(1997)
淡江大學化學系學士(1982-1986) |
Tamkang University , Assistant Professor
Academia Sinica, Postdoctoral Research Fellow
National Tsing Hua University , Ph.D.
Tamkang University , B.S. |
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研究方向
- 生醫核磁共振
- 物理化學
- 結構生物學
研究興趣
- 利用核磁共振方法研究生物分子之結構,包括生物分子之溶液結構、動態行為、ligand-receptor作用的影響等。
- 以高解析固態MAS方法,進行 ex vivo 細胞疾病之生理代謝研究。
Our researches focus on :
By using NMR methods to investigate biomolecular structures including solution structure, molecular dynamics and ligand-receptor binding.
By using ex vivo HRMAS to investigate correlation of cellular biochemical changes and different pathologies.
E-mail: cshlee@mail.tku.edu.tw |
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代表性著作
- Teng-Yi Huang, Hsiao-Wen Chung, Ming-Yen Chen, Lung-Hui Giiang, Shy-Chyi Chin, Chang-Shin Lee, Cheng-Yu Chen, Yi-Jui Liu. Quantification of supratentorial CSF production rate in healthy adults: A high temporal and spatial resolution 2D cine phase-contrast MRI study. Radiology 2004; 233(2):603-8
- Wen-Chau Wu, Chao-Ching Huang, Hsiao-Wen Chung, Michelle Liou, Chun-Jen Hsueh, Chang-Shin Lee, Ming-Long Wu, Cheng-Yu Chen. Hippocampal Alterations in Children with Temporal Lobe Epilepsy with or without a History of Febrile Convulsions: Evaluations with MR Volumetry and Proton MR Spectroscopy. AJNR Am J Neuroradiol. 2005 May;26(5):1270-5.
- Yi-Fang Tu, Cheng-Yu Chen, Chao-Ching Huang, Chang-Shin Lee. Vacuolating megalencephalic leukoencephalopathy with mild clinical course validated by diffusion tensor imaging and MR spectroscopy. AJNR Am J Neuroradiol. 2004 Jun-Jul;25(6):1041-5.
- Yi-Jui Liu, Cheng-Yu Chen, Hsiao-Wen Chung, Ing-Jye Huang, Chang-Shin Lee, Shy-Chyi Chin, Michelle Liou. Temporal evolution of neuronal necrosis following ischemic injury in the middle cerebral artery territory: deep watershed versus territorial infarct subtypes on MR perfusion and spectroscopic imagings. Radiology. 2003;229:366-374
- Yi-Jui Liu, Hsiao-Wen Chung, Ing-Jye Huang, Fu-Nien Wang, Shy-Chyi Chin, Chang-Shin Lee, Cheng-Yu Chen. J. Neuroimaging, 2002;12:330-338.
- Lee, W. T., Lee, C. S., Pan, Y. L. and Chang C. “Temporal Changes of Cerebral Metabolites and Striatal Lesions in Acute 3-Nitropropionic Acid Intoxication in the Rat”Magn. Res. Med. 2000, 44, 29-34.
- Lee, C. S., Kumar, T. K. S., Cheng, J. W., Yu, C. Main-Chain Internal Dynamics of Cardiotoxin II from Taiwan Cobra as Studied by Carbon-13 NMR at Natural Abundance: Delineation of the role of functionally important residues,” Biochemistry 1998, 37,
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