淡江大學 | 中文 | English

 

謝仁傑(Jen-Chieh Hsieh)

有機合成  天然物合成


學歷: 
清華大學化學所博士 2006
清華大學化工所碩士 2002
清華大學化學系學士 2000
經歷: 
淡江大學化學系專任教授     2017,2 迄今
淡江大學化學系專任副教授   2013~2017
淡江大學化學系專任助理教授 2010~2013
日本京都大學博士後研究員(JSPS 特別研究員) 2010,8
奧地利維也納理工大學博士後訪問學者 2009,3
美國德州西南醫學中心博士後研究員 2008,8
Education:
Ph. D. in Chemistry, National Tsing Hua University, 2006.
MS. in Chemical engineering, National Tsing Hua University, 2002.
BS. in Chemistry, National Tsing Hua University, 2000.
 
Employment History:
Professor (2017 to present)
Associate Professor (2013 to 2017)
Assistant Professor  (2010 to 2013)
Postdoctoral fellow in Kyoto University (2010,8)
Visiting scholar in Vienna University of Technology (2009,3)
Postdoctoral fellow in UT Southwestern Medical Center (2008,8)

 


謝仁傑

辦公室:C449 (化學系舊館、傳播館四樓)
實驗室:C435 (化學系舊館、傳播館四樓)
TEL : (02) 2621-5656 轉 2545 
E-mail address : jchsieh@mail.tku.edu.tw

 

研究專長及興趣

新型態有機合成方法研究 天然物合成 藥物合成 

(Synthetic methodology, Natural alkaloids synthesis, Pharmaceutical synthesis)

 實驗室合照

International Award:
2015 Asian Core Program Lectureship Award (Japan)
2015 Asian Core Program Lectureship Award (Singapore)
JSPS (Japan Society for the Promotion of Science) researcher fellowship (台灣第一位受獎人)
FWF (Förderung der wissenschaftlichen Forschung) fellowship

 

Publication list

 

Journal papers:

1. Hsieh, J.-C.,* Hong, Y.-C.; Yang, C.-M.; Cheng, C.-H.* Org. Chem. Front. 2017, 4, 1615–1619. “Nickel‑Catalyzed Highly Chemo- and Stereoselectively Borylative Cyclization of 1,6-Enynes with Bis(pinacolato)diboron

2. Chen, W.-L.; Jhang, Y.-Y.; Hsieh, J.-C.* Res. Chem. Intermed. 2017, 43, 3517–3526. “Copper-Catalyzed Intramolecular C-N Coupling Reaction of Aryl Halide with Amide

3. Fan-Chiang, T.-T.; Wang, H.-K.; Hsieh, J.-C.* Tetrahedron 2016, 72, 5640–5645. “Synthesis of Phenanthridine Skeletal Amaryllidaceae Alkaloids

4. Jhang, Y.-Y.; Fan-Chiang, T.-T.; Huang, J.-M.; Hsieh, J.-C.* Org. Lett. 2016, 18, 1154–1157. “Copper-Catalyzed Annulation: A Method for the Systematic Synthesis of Phenanthridinium Bromide

5. Gopula, B.; Yang, S.-H.; Kuo, T.-S.; Hsieh, J.-C.;* Wu, P.-Y.; Henschke, J. P.;* Wu, H.-L.* Chem. Eur. J. 2015, 21, 11050–11055. “Direct Synthesis of Chiral 3-Arylsuccinimides by Rhodium-Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides

6. Liu, C.-C.; Hsieh, J.-C.;* Korivi, R.-P.; Cheng, C.-H.* Chem. Eur. J. 2015, 21, 9544–9549. “Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones

7. Chen, W.-L.; Chen, C.-Y.; Chen, Y.-F.; Hsieh, J.-C.* Org. Lett. 2015, 17, 1613–1616. ”Hydride-Induced Anionic Cyclization: An Efficient Method for the Synthesis of 6-H-Phenanthridines via a Transition-Metal-Free Process

8. Chen, Y.-F.; Hsieh, J.-C.* Synfacts, 2014, 10, 1194. “Synthesis of Polysubstituted Phenanthridines

9. Chen, Y.-F.; Hsieh, J.-C.* Org. Lett. 2014, 16, 4642–4645. “Synthesis of Polysubstituted Phenanthridines via Ligand-Free Copper-Catalyzed Annulation

10. Chen, Y.-F.; Wu, Y.-S.; Jhan, Y.-H.; Hsieh, J.-C.* Org. Chem. Front. 2014, 1, 253–257. “An Efficient Synthesis of (NH)-Phenanthridinones via Ligand-Free Copper-Catalyzed Annulation

11. Wan, J.-C.; Huang, J.-M.; Jhan, Y.-H.; Hsieh, J.-C.* Synfacts, 2013, 9, 948. “Nitrile-Directed Palladium-Catalyzed Syntheses of Fluorenones

12. Wan, J.-C.; Huang, J.-M.; Jhan, Y.-H.; Hsieh, J.-C.* Org. Lett. 2013, 15, 2742–2745. “Novel Syntheses of Fluorenones via Nitrile Directed Palladium-Catalyzed C­H and Dual C­H Bond Activation

13. Jhan, Y.-H.; Kang, T.-W.; Hsieh, J.-C.* Tetrahedron Lett. 2013, 54, 1155–1159. “Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles”

14. Hsieh, J.-C.;* Cheng, A.-Y.; Fu, J.-H.; Kang, T.-W. Org. Biomol. Chem. 2012, 10, 6404–6409. “Copper-Catalyzed Domino Coupling Reaction: An Efficient Method to Synthesize Oxindoles

15. Hsieh, J.-C.;* Chen, Y.-C.; Cheng, A.-Y.; Tseng, H.-C. Org. Lett. 2012, 14, 1282–1285. “Nickel-Catalyzed Intermolecular Insertion of Aryl Iodides to Nitriles: A Novel Method to Synthesize Arylketones

16. Lee, Y.-H.; Chen, Y.-C.; Hsieh, J.-C.* Eur. J. Org. Chem. 2012, 247–250. “Pyridine-Catalyzed Double C–N Coupling Reaction of an Isocyanate with two Benzynes

17. Cheng, A.-Y.; Hsieh, J.-C.* Tetrahedron Lett. 2012, 53, 71–75. “Highly Efficient Copper Catalytic System for the O-Arylation of Phenol with Iodoarene

18. Lackner-Warton, W.; Tanaka, S.; Standfest-Hauser, C. M.; Öztopcu, Ö.; Hsieh, J.-C.; Mereiter, K.; Kirchner, K.* Polyhedron, 2010, 29, 3097–3102. "Synthesis and characterization of ruthenium p-cymene complexes bearing bidentate P–N and E–N ligands (E = S, Se) based on 2-aminopyridine"

19. Hsieh, J.-C.; Ebata, S.; Nakao, Y.;* Hiyama, T.* Synlett, 2010, 1709–1711. “Asymmetric Synthesis of Indolines Bearing Benzylic Quaternary Carbon Center through Intramolecular Arylcyanation of Alkenes

20. Lu, J.; Ma, Z.; Hsieh, J.-C.; Fan, C.-W.; Chen, B.; Longgood, J. C.; Williams, N. S.; Amatruda, J. F.; Lum, L.; Chen, C.* Bioorg. Med. Chem. Lett. 2009, 19, 3825–3827. “Structure–activity relationship studies of small-molecule inhibitors of Wnt response

21. Hsieh, J.-C.; Cheng, C.-H.* Chem. Commun. 2008, 2992–2994. “O-Dihaloarenes as aryne precursors for nickel-catalyzed [2+2+2] cycloaddition with alkyne and nitriles

22. Hsieh, J.-C.; Cheng, C.-H.* Chem. Commun. 2005, 4554–4556. “Nickel-catalyzed coupling of isocyanates with 1,3-iodoesters and halobenzenes: a novel method for the synthesis of imide and amide derivatives

23. Hsieh, J.-C.; Cheng, C.-H.* Chem. Commun. 2005, 2459–2461. “Nickel-catalyzed cocyclotrimerization of arynes with diynes; a novel method for synthesis of naphthalene derivatives

24. Hsieh, J.-C.; Rayabarapu, D. K.; Cheng, C.-H.* Chem. Commun. 2004, 532–533. “Nickel-catalyzed highly chemoselective cocyclotrimerization of arynes with allenes: a novel method for 10-methylene-9,10-dihydrophenanthrenes

25. Ma, C.C. M.;* Kuan, H.-C.; Hsieh, J.-C.; Chiang, C.-L. J. Mate. Sci. 2003, 38, 3933–3944. “Effects of chain extender and hard/soft segment content on the surface and electrical properties of PDMS based polyurea-urethane

 

International Conference:

1. Hsieh, J.-C.* Invited speaker in Chemistry for Creative Economy, Hsinchu, Taiwan, 2017. “Metal-Mediated C-N Annulation Reactions and the Application to Synthesize Natural Alkaloids”

2. Hsieh, J.-C.* Invited speaker in C&FC, Taipei, Taiwan, 2016. “Syntheses of Phenanthridine Derivatives via Metal-Mediated C-N Annulation Reactions

3. Hsieh, J.-C.* ICCEOCA-11, Daejeon, Korea, 2016. “Application of C-N Coupling Reactions to Synthesize the Amaryllidaceae Alkaloids

4. Hsieh, J.-C.* Invited speaker in ISOR-12, Kyoto, Japan, 2016. “Novel Synthetic Route to the Amaryllidaceae Alkaloids

5. Hsieh, J.-C.* IKCOC-13, Kyoto, Japan, 2015. “Synthesis of Phenanthridines and Phenanthridinones via the Transformation of Nitrile

6. Hsieh, J.-C.* ICCEOCA-10, Kaohsiung, Taiwan, 2015. “Transformation of Biaryl Nitriles to form the Phenanthridine Derivatives

7. Hsieh, J.-C.* Invited speaker in ICCC-41, Singapore, 2014. “Palladium Catalyzed Remote C­H and Dual C­H Bond Activation: Novel Syntheses of Fluorenones

8. Hsieh, J.-C.* ICOMC-26, Sapporo, Japan, 2014. “Metal-Catalyzed Coupling Reactions Involving Nitrile and Application in the Syntheses of Natural Alkaloids

9. Hsieh, J.-C.* Invited speaker in ISOR-11, Taipei, Taiwan, 2013. “Palladium Catalyzed Remote C­H and Dual C­H Bond Activation: Novel Syntheses of Fluorenones

10. Hsieh, J.-C.* IKCOC-12, Kyoto, Japan, 2012. “Nickel-Catalyzed Intermolecular Insertion of Aryl Iodides to Nitriles: A Novel Method to Synthesize Arylketones

11. Hsieh, J.-C.* Invited speaker in WOCJC-7 Symposium, Tokyo, Japan, 2011. “Pyridine-Catalyzed Double CN Coupling Reaction of an Isocyanate with two Benzynes”

12. Hsieh, J.-C.; Ebata, S.; Yada, A.; Nakao, Y.;* Hiyama, T.* The 11th International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto, Japan, 2009. “Nickel/Lewis Acid-catalyzed Enantioselective Intramolecular Arylcyanation of Alkene

13. Hsieh, J.-C.; Cheng, C.-H.* NTHU-KAIST 2005 Junior Chemists Workshop, Hsinchu, 2005. “Nickel-catalyzed cocyclotrimerization of arynes with allenes”

14. Hsieh, J.-C.; Cheng, C.-H.* The 10th International Chemical Conference, Taipei, R.O.C., 2005. “Nickel-catalyzed cocyclotrimerization of arynes with allenes and alkynes”

15. Hsieh, J.-C.; Cheng, C.-H.* The 7th IUPAC International Conference on Heteroatom Chemistry (ICHAC-7), Shanghai, China, 2004. “Nickel-catalyzed highly chemoselective cocyclotrimerization of arynes with allenes: a novel method for 10-methylene-9,10-dihydrophenanthrenes”