淡江大學 | 中文 | English

 

黃家琪（Chia-Chi Huang）
分析化學、食品化學、光譜技術平台建立與檢測、奈米材料合成與應用
 
現任: 
 
淡江大學化學系 - 專任助理教授 (2021 ~ 迄今)
 
實驗室主持人 - 光譜感測與先進材料實驗室 (2021 ~ 迄今)
 
Review Editor - Frontiers in Analytical Chemistry (2021 ~迄今)
 
美國化學學會會員 (2021~迄今)
 
 
經歷：
 
嘉義大學應用化學系 - 專案助理教授 (2016 ~ 2021)
 
執行編輯 - Journal of Traditional and Complementary Medicine
 
(2013 ~ 2016)
 
博士後研究員 - 台灣大學食品與生物分子中心 (2013 ~ 2016)
 
食品安全系列講座講師 - 台灣食品保護協會 (2015 ~ 2016)
 
博士後研究員 - 中正大學奈米生物檢測科技研究中心 (2012 ~ 2013)
 
 
 
 
 
 
Assistant Professor - Department of Chemistry, Tamkang University (2021 ~)
 
Leader -  Laboratories of Spectroscopic Sensing and Advanced Materials (2021 ~)
 
Review Editor - Frontiers in Analytical Chemistry (2021 ~)
 
Regular Member - American Chemical Society (2021 ~)
 
Assistant Professor (non-tenure track position), Department of Applied Chemistry, Chiayi University (2016 ~ 2021)
 
Managing Editor, Journal of Traditional and Complementary Medicine (2013 ~ 2016)
 
Postdoc, National Taiwan University (2013 ~ 2016)
 
Lecture, Association for Food Protection (2015 ~ 2016)
 
Postdoc, National Chung Cheng University (2012 ~ 2013)
黃家琪

連絡方式與連結：

e-mail address: cch@mail.tku.edu.tw 

Researchgate: https://www.researchgate.net/profile/Chia_Chi_Huang2

Google Scholar: https://scholar.google.com/citations?user=WgLq9VoAAAAJ&hl=en

 

研究方向：

本研究團隊致力於拉曼光譜、表面增強拉曼光譜、螢光光譜的分析，建立多功效平台以應用於化學、醫學、食品、環境之實際檢測；除此之外，我們也涉及有機化學方法合成光敏物質和奈米材料，嘗試發展光與電的轉換模組與抗菌材質。 我們非常歡迎肯努力做研究的同學一起共事。

 

光譜感測與先進材料實驗室近年的工作包括 (誠摯歡迎有志一同努力研究的同學加入本實驗室)：

我們的研究策略是同時探討表面增強拉曼與螢光兩個獨立的光學現象，目的是建立分子光譜分析技術來觀測分子模式，亦可使成果外溢到檢測應用的發展。在表面增強拉曼方面，(A) 我們利用奈米碳點創造奈米銀聚集團中的特殊空隙作為能量傳遞的3D空間；(B) 我們建立了基質的雙重載體技術；(C) 我們建立了在原始介質中辨識蛋白的拉曼光譜能力；(D) 我們建立了拉曼光譜統計分析的模型。另外，我們發表了極高靈敏度的拉曼光譜量測技術。 在螢光方面，我們成功製備了好幾種螢光碳點及衍生物和光敏劑，並已經初步達成了提升油溶性、可承載生物活性分子等目標，以擴大螢光標定的應用範圍。

以下為實驗室發表的重要貢獻:

1.  3D空間的建構 – 以不同螢光碳點構築不同的奈米銀聚集團形成特殊角錐空間，此結果發表在2023年Nanoscale。

2.  開發雙重載體技術 –

     - 剛性SERS載台，報導多樣的食品染料偵測技術，乃至於應用於真實樣品。 光譜的偵測極限為10-15 M。此結果於2022年刊登在Food Chemistry。

     - 軟性SERS載台，此結果除了顯示表面增強拉曼光譜技術的偵測外，亦可當作產氫的加速催化劑。 2022年發表於ACS Applied Nano Materials。

3.  以拉曼光譜的蛋白辨識能力爲主的化學結構分類技術 – 以骨頭形狀的奈米金棒，報導了Trimeresurus stejnegeri和Bungarus multicinctus毒液的SERS光譜。光譜顯示出蛇毒的獨特SERS標記，在2020年發表於Journal of Materials Chemistry B。

4.  針對複雜真實樣品分析的拉曼光譜統計分析技術 – 已經以28種類黃酮為模型建立一套有效方法，成果論文已發表於Journal of Food and Drug Analysis (2020) 28:45。

5.  極高靈敏度拉曼光譜量測技術 – 已經建立高度靈敏(10-18 M)的液相表面增强拉曼量測技術 "A SERS method with attomolar sensitivity: a case study with the flavonoid catechin"，發表於：Microchim Acta (2018) 185: 120。

 

團隊成員：

多光譜檢測平台 (Sensor): 張嘉彣 (研究生)、林芷榆 (研究生)、陳妍如 (專題生)

應用能源材料 (Applied Energy Materials): 余浚希 (專題生)、周俐妤 (專題生)、連品源 (專題生)

應用奈米材料 (Applied Nano Materials) & 程式語言設計 (Programming language) : 王俊皓 (專題生)、游晴伃 (專題生)

感謝已畢業的團隊成員：

鄭棋云 (2020 嘉義大學應化系畢業)

黃于庭 (2020 嘉義大學應化所畢業)

簡佑珊 (2021 嘉義大學應化所畢業)

徐子涵 (2021 嘉義大學應化所畢業)

洪藝珊 (2022 嘉義大學應化所畢業)

黃韋綸 (2023 嘉義大學應化所畢業)

沈怡蓁 (2023 嘉義大學應化系畢業)

游芸綺 (2023 嘉義大學應化系畢業)

徐  立  (2023 淡江大學 尖端材料科學學士學程畢業)

 

合作夥伴：

陳文龍教授 - 嘉義大學應用化學系

盧冠宏教授 - 台灣大學食品安全與健康研究所

張玉明研究員 - 台灣大學凝態科學研究中心

郭煌政教授 - 嘉義大學資訊工程系

Dr. Yen-Shi Lai, Colossus BioPharma Consultants Co., Ltd, Taiwan  

 

 

期刊著作：

1.   Matthew Heras, Chia-Chi Huang, Ching-Wen Chang*, Kuan-Hung Lu*, "Trends in chitosan-based films and coatings: A systematic review of the incorporated biopreservatives, biological properties, and nanotechnology applications in meat preservation", Food Packaging and Shelf Life, Food Packaging and Shelf Life (2024) 42: 101259,  IF=8.0; Ranking: 11/142, FOOD SCIENCE & TECHNOLOGY. 

2.      Wei-Lun Huang, Chia-Jung Hsu, Jun Hao Wang, Zi-Han Hsu, Kuan-Hung Lu, Wen-Der Wang, Chia-Chi Huang*, "Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging”, ACS Applied Nano Materials (2023) 6: 19200, IF= 5.9; Ranking: 46/109, NANOSCIENCE & NANOTECHNOLOGY. 

3.      Yi-Shan Hung, Chia-Wen Chang, Yi Chen Shen , Yun-Chi Yu, Wei-Lun Huang, Chia-Chi Huang*, "Spectroscopic Analyses of Particle and Energy Aggregations at the Interface of Silver Nanoparticles and Fluorescent Carbon Nanodots", Nanoscale (2023) 15: 13987.  (本篇文章獲選為期刊內封底 Inside Back Cover),  IF= 6.700; Ranking: 43/178, CHEMISTRY, MULTIDISCIPLINARY. 

4.      Zi-Han Hsu, Li Hsu, Chia-Chi Huang*, "Polyacrylamide Gel Scaffold Immobilized with Silver Nanoparticles as SERS Substrates and Catalysts for H2 Generation via Methanolysis of NaBH4,"   ACS Applied Nano Materials (2022) 5:2258, IF= 5.9; Ranking: 46/109, NANOSCIENCE & NANOTECHNOLOGY. 

5.      Yu-San Chien, Chia-Wen Chang, Chia-Chi Huang*, "Differential Surface Partitioning for An Ultrasensitive Solid-State SERS Sensor and Its Application to Food Colorant Analysis," Food Chemistry (2022) 383:132415, IF= 9.231; Ranking: 7/74, CHEMISTRY APPLIED. 

6.      Chia-Chi Huang*, Zi-Han Hsu, Yen-Shi Lai, "Raman Spectroscopy for Virus Detection and The Implementation of Unorthodox Food Safety," Trends in Food Science & Technology (2021) 116:525, IF: 16.002; Ranking: 2/143, FOOD SCIENCE AND TECHNOLOGY.  

7.      Chia-Chi Huang*, Yen-Shi Lai, Chih-Hsien Wang, Lai-Kwan Chau, Wenlung Chen*, "Label-Free SERS Characterization of Snake Venoms by Exploring the Cysteine Environs with Bone-Shaped Gold Nanoparticles," Journal of Materials Chemistry B (2020) 8:10744. IF: 7.571; Rank: 10/44, MATERIAL SCIENCE, BIOMATERIALS. (本篇文章獲選為期刊封底 Back Cover)

8.      Chia-Chi Huang*, Chi-Yun Cheng, Yen-Shi Lai, "Paper-Based Flexible Surface Enhanced Raman Scattering Platforms and Their Applications to Food Safety," Trends in Food Science & Technology (2020) 100:349, IF: 16.002; Ranking: 2/143, FOOD SCIENCE AND TECHNOLOGY.

9.      Chia-Chi Huang*, "Unusual Diets in A Pandemic Crisis," Journal of Dietetics and Food Technology (2020) 1: 005. 

10.   Chih-Hsien Wang, Chia-Chi Huang*, Wenlung Chen*, and Yen-Shi Lai, "The Chemical Aspects of Raman Spectroscopy: Statistical Structure-Spectrum Relationship in The Analyses of Flavonoids," Journal of Food and Drug Analysis (2020) 28:45. IF: 6.157; Rank: 27/143, FOOD SCIENCE AND TECHNOLOGY.

11.   Chia-Chi Huang*, Yi-Shan Hung, Yih-Ming Weng, Wenlung Chen, Yen-Shi Lai, "Sustainable Development of Carbon Nanodots Technology: Natural Products as A Carbon Source and Applications to Food Safety," Trends in Food Science & Technology (2019) 86:144, IF: 16.002; Ranking: 2/143, FOOD SCIENCE AND TECHNOLOGY.

12.   Chia-Chi Huang*, Chi-Yun Cheng, Chao-Ting Chou and Wenlung Chen*, "Adsorbate Enrichment on Zeolite Surface and Assembly of A SERS Sensor: A Case Study with Silver Nanoparticles and The Flavonoid Catechin," RSC Advances (2019) 9:1048, IF: 4.036; Ranking: 75/179, CHEMISTRY, MULTIDISCIPLINARY.

13.   Chia-Chi Huang*, Wenlung Chen*, "A SERS method with attomolar sensitivity: a case study with the flavonoid catechin," Microchimica Acta (2018) 185: 120.  IF: 6.408; Rank: 13/87, CHEMISTRY, ANALYTICAL.

14.   Chia-Chi Huang*, Wenlung Chen*, "Raman Spectroscopic Analysis of Cataract Lens: A Compendious Review," Applied Spectroscopy Reviews (2018) 53: 689.  IF: 5.010; Rank: 4/43, SPECTROSCOPY.

15.   Cheng-Liang Huang, Chia-Chi Huang*, Wenlung Chen*, "A Report from the 5th International Taiwan Symposium on Raman Spectroscopy (TISRS 2017) and Taiwan Association of Raman Spectroscopy (TARS) Summer Camp," Journal of Raman Spectroscopy (2018) 49: 594.  IF: 2.727; Rank: 17/43, SPECTROSCOPY.

16.   Chih-Hsien Wang, Chia-Chi Huang, and Wenlung Chen*, "Simultaneous Separation of Txon-Specific Crystallins from Mule Duck and Characterization of Their Enzymatic Activities and Structures," Journal of Chromatography B (2017) 1053: 34. IF: 1.913; Rank: 20/68, CHEMISTRY, ANALYTICAL.

17.   Chia-Chi Huang*, Ciro Isidoro**, "Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease," Journal of Alzheimer's Disease (2017) 57: 1145. IF: 4.160; Rank: 121/274, NEUROSCIENCES.

18.   Chih-Wei Hsu, Chia-Chi Huang, Jeng-Horng Sheu, Chia-Wen Lin, Lien-Fu Lin, Jong-Shiaw Jin, Lai-Kwan Chau, Wenlung Chen*, "Novel Method for Differentiating Histological Types of Gastric Adenocarcinoma by Using Confocal Raman Microspectroscopy," PLoS ONE (2016) 11: e0159829. IF: 3.752; Rank: 29/73, MULTIDISCIPLINARY SCIENCES.

19.   Chih-Wei Hsu, Chia-Chi Huang, Jeng-Horng Sheu, Chia-Wen Lin, Lien-Fu Lin, Jong-Shiaw Jin, Wenlung Chen*, "Differentiating Gastrointestinal Stromal Tumors from Gastric Adenocarcinomas and Normal Mucosae Using Confocal Raman Microspectroscopy," Journal of Biomedical Optics (2016) 21: 075006. IF: 3.758; Rank: 29/101, OPTICS.

20.   Chih-Hsien Wang, Chia-Chi Huang, Long-Liu Lin and Wenlung Chen*, "The Effected of Disulfide Bonds on Protein Folding, Unfolding, and Misfolding Investigated by FT-Raman Spectroscopy," Journal of Raman Spectroscopy (2016) 49: 594. IF: 2.727; Rank: 17/43, SPECTROSCOPY.

21.   Lien-Fu Lin, Jong-Shiaw Jin, Jui-Chang Chen, Chia-Chi Huang, Jeng-Horng Sheu, Wenlung Chen, Tang Yi Tsao, Chih-Wei Hsu*, "Positive Cyclin T expression as a Favorable Prognostic Factor in Treating Gastric Gastrointestinal Stromal Tumors", Molecular and Clinical Oncology (2016) 4: 971. Rank: 269/317, ONCOLOGY.

22.   Chia-Chi Huang*, "Applications of Raman Spectroscopy in Herbal Medicine," Applied Spectroscopy Reviews (2016) 51: 1.  IF: 5.010; Rank: 4/43, SPECTROSCOPY.

23.   Ciro Isidoro*, Chia-Chi Huang, Lee-Yan Sheen*, "Publishing Scientifically Sound Papers in Traditional and Complementary Medicine," Journal of Traditional and Complementary Medicine, 6 (2016) 1-4. IF: 4.221; Rank: 8/30, INTEGRATIVE & COMPLEMENTARY MEDICINE. 

24.   Ciro Isidoro*, Chia-Chi Huang, Lee-Yan Sheen*, "Report from the Second International Conference of Traditional and Complementary Medicine on Health 2015," Journal of Traditional and Complementary Medicine, 6 (2016) 5-9. IF: 4.221; Rank: 8/30, INTEGRATIVE & COMPLEMENTARY MEDICINE.

25.   Jong-Shiaw Jin, Lien-Fu Lin, Jui-Chang Chen, Chia-Chi Huang, Jeng-Horng Sheu, Wenlung Chen, Tang-Yi Tsao, Chih-Wei Hsu*, "Increased Cyclin T1 Expression as a Favorable Prognostic Factor in Treating Gastric Adenocarcinoma," Oncology Letters (2015) 10: 3712.  IF: 3.111; Rank: 176/245, ONCOLOGY.

26.   Chia-Chi Huang, Chen-Han Huang, I-Ting Kuo, Lai-Kwan Chau*, Tzzy-Schiuan Yang*, "Synthesis of Silica-coated Gold Nanorod as Raman Tags by Modulating Cetyltrimethylammonium Bromide Concentration," Colloids and Surfaces A (2012) 409: 61.  IF: 5.518; Rank: 61/163, CHEMISTRY/PHYSICAL.

27.   Hsing-Ying Lin, Chen-Han Huang, Chia-Chi Huang, Yu-Chia Liu, and Lai-Kwan Chau*, "Multiple Resonance Fiber-Optic Sensor with Time Division Multiplexing for Multianalyte Detection," Optics Letters (2012) 37: 3969.  IF: 3.560; Rank: 32/101, OPTICS.

28.   Le Dac Tuyen, An Chi Liu, Chia-Chi Huang, Pei-Cheng Tsai, Jian Hung Lin, Chin-Wei Wu, Lai-Kwan Chau*, Tzyy Schiuan Yang, Le Quoc Minh, Hung-Chih Kan*, and Chia Chen Hsu*, "Doubly Resonant Surface-Enhanced Raman Scattering on Gold Nanorod Decorated Inverse Opal Photonic Crystals," Optics Express (2012) 20: 29266.  IF: 3.833; Rank: 28/101, OPTICS.

29.   Cheng Yi Wu, Chia Chi Huang, Jia Sin Jhang, An Chi Liu, Chun-Chen Chiang, Ming-Lung Hsieh, Ping-Ji Huang, Le Dac Tuyen, Le Quoc Minh, Tzyy-Schiuan Yang, Lai-Kwan Chau, Hung-Chih Kan*, and Chia Chen Hsu*, "Hybrid Surface-Enhanced Raman Scattering Substrate from Gold Nanoparticle and Photonic Crystal: Maneuverability and Uniformity of Raman Spectra," Optics Express (2009) 20: 29266. IF: 3.833; Rank: 28/101, OPTICS.

 

 

 

研討會論文：

 

國際研討會 – 受邀演講 (Invited Speaker)：

1.  "The detection of food colorants by an ultrasensitive solid-state SERS sensor", Taiwan International Symposium on Raman Spectroscopy and Taiwan Association of Raman Spectroscopy, Japan, 2022. 
2.  "A Rapid and Sensitive SERS Detection of Catechin in Green Tea Beverages," The 6th Taiwan International Symposium on Raman Spectroscopy (TISRS 2018) and Taiwan Association of Raman Spectroscopy, Japan, 2018.
3. "Ultrasensitive SERS detection of catechin in solution," The 5th International Congress on Microscopy and Spectroscopy, Turkey, 2018.
4.  "A simple and effective way to fabricate a silica-coated gold nanorod as a Raman-fluorescence dual tag," The 1st Taiwan International Symposium on Raman Spectroscopy, Taiwan, 2013.
 
國際研討會 - 口頭報告 (Oral Presentation)：
1. "A Novel Confocal Raman Microspectroscopic Method for Recognizing Gastric Adenocarcinoma and Gastrointestinal Stromal Tumors," The 26th International Conference on Raman Spectroscopy (ICORS 2018), Korea, 2018.
 
國內研討會/會議 – 受邀演講 (Invited Speaker)：
1. "Label-Free SERS Sensing of Snake Venoms"，第二十六屆 分析技術交流研討會，輔仁大學，2021。
2. "表面增強拉曼散射光譜與共軛焦顯微拉曼光譜技術之檢測應用"，分析小組春季會議，高雄醫學大學，2019。
3. "食品安全容器與健康-淺談美耐皿"，財團法人塑膠工業技術發展中心，2017。
4.  "學術期刊編輯之工作經驗分享"，南華大學，2017。
5.  "國際科學期刊投審稿流程與工作經驗分享"，中正大學，2014。